The 2000 San Juan, Puerto Rico mayoral election was held on November 7, 2000 to elect the mayor of San Juan, Puerto Rico. It was held as part of the 2000 Puerto Rican general election. It saw the election of Jorge Santini, a member of the New Progressive Party.
Incumbent mayor Sila María Calderón, a member of the Popular Democratic Party, did not seek reelection to a second term, and instead ran for governor.