The Maltese First Division knock-out 2006–07 (known as EuroSport First Division knock-out 2006-07 due to sponsorship reasons) was a knock-out competition for Maltese football clubs from the First Division.The winners were Tarxien and the runner-up were Mosta.
The competition began on 18 November 2006 and ended on 24 May 2007 with the final.
The competition began with the preliminary round. Four teams played in the preliminary round. The two winners from the preliminary round advanced to the quarterfinals with the rest of the teams of the First Division. The four winners of the quarterfinals, which were Mosta, Senglea, St.Patrick and Tarxien advanced to the semifinals.
