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The 2010 Copa Colombia, officially the 2010 Copa Postobón for sponsorship reasons, was the eighth edition of the Copa Colombia, the national cup competition for clubs of DIMAYOR. It began on February 24 and ended on November 3. The winner, Deportivo Cali, earned a berth in the 2011 Copa Sudamericana.
The format for 2010 differs from last year's. A total of 16 teams (instead of 12), which include the group winners, runners-up, and the four best third-placed teams, advance from the first phase to the second phase.
Phase I[]
Teams advanced to Phase II
Group A[]
Group A comprises teams from the Caribbean Region.