The 2016 Three Days of De Panne (Dutch: Driedaagse De Panne–Koksijde) was the 40th edition of the Three Days of De Panne cycling stage race. The race included four stages, two of which took place on the final day. It was rated as a 2.HC event in the 2016 UCI Europe Tour.
22 teams took part in the 2016 Three Days of De Panne. 11 of these were UCI WorldTeams and the remaining 11 were UCI Professional Continental teams.[1]Wanty–Groupe Gobert withdrew before the start of the race on Monday 28 March after the death of Antoine Demoitié in Gent–Wevelgem a day earlier.[2]