The 2019 Colorado Buffaloes football team represented the University of Colorado Boulder during the 2019 NCAA Division I FBS football season. The Buffaloes were led by first-year head coach Mel Tucker and played their home games on campus at Folsom Field. They competed as a member of the South Division of the Pac-12 Conference. They finished the season 5–7, 3–6 in Pac-12 play to finish in fifth place in the South Division.
Colorado's 2019 schedule began on Friday, August 30 with a non-conference neutral site game against in-state rivalColorado State in Denver. The Buffaloes will then play two more non-conference games at home, first against traditional Big Eight Conference rival Nebraska, now a member of the Big Ten Conference, and then against in-state foe Air Force, a member of the Mountain West Conference along with Colorado State. In Pac-12 Conference play, Colorado will play the other members of the South Division and draws Oregon, Stanford, Washington, and Washington State from the North Division. They will not play California or Oregon State as part of the regular season.