ABI1

ABI1
Identifiers
Aliases	ABI1, ABI-1, ABLBP4, E3B1, NAP1BP, SSH3BP, SSH3BP1, abl interactor 1
External IDs	OMIM: 603050 MGI: 104913 HomoloGene: 38053 GeneCards: ABI1
showGene location (Human)
Chr.	Chromosome 10 (human)
End	26,861,087 bp
showGene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	23,040,241 bp
showRNA expression pattern
	; ;
	More reference expression data
showGene ontology
Molecular function	• protein tyrosine kinase activator activity; • GO:0032403 protein-containing complex binding; • cytoskeletal protein binding; • GO:0001948 protein binding; • SH3 domain binding; • cadherin binding;
Cellular component	• cytoplasm; • cytosol; • postsynaptic membrane; • cell projection; • GO:0097483, GO:0097481 postsynaptic density; • SCAR complex; • membrane; • filopodium; • growth cone; • plasma membrane; • synapse; • intracellular anatomical structure; • cell junction; • cell leading edge; • endoplasmic reticulum; • neuron projection; • extracellular exosome; • cytoskeleton; • nucleus; • lamellipodium; • filopodium tip;
Biological process	• somitogenesis; �� megakaryocyte development; • movement of cell or subcellular component; • Fc-gamma receptor signaling pathway involved in phagocytosis; • transmembrane receptor protein tyrosine kinase signaling pathway; • positive regulation of protein tyrosine kinase activity; • vascular endothelial growth factor receptor signaling pathway; • peptidyl-tyrosine phosphorylation; • GO:0022415 viral process; • lamellipodium morphogenesis; • negative regulation of cell population proliferation; • dendrite morphogenesis; • actin polymerization or depolymerization;
	Sources:Amigo / QuickGO
Orthologs
	10006
	11308
	ENSG00000136754
	ENSMUSG00000058835
	Q8IZP0
	Q8CBW3
showNM_001012750; NM_001012751; NM_001012752; NM_001178116; NM_001178119;
	NM_001178120; NM_001178121; NM_001178122; NM_001178123; NM_001178124; NM_001178125; NM_005470; NM_001348029; NM_001348030; NM_001348031; NM_001348032; NM_001348033; NM_001348034
showNM_001077190; NM_001077192; NM_001077193; NM_007380; NM_145994;
	NM_001331043; NM_001331044; NM_001331045; NM_001377510; NM_001377511; NM_001377512; NM_001377513
showNP_001012768; NP_001012769; NP_001012770; NP_001171587; NP_001171590;
	NP_001171591; NP_001171592; NP_001171593; NP_001171594; NP_001171595; NP_001171596; NP_005461; NP_001334958; NP_001334959; NP_001334960; NP_001334961; NP_001334962; NP_001334963
showNP_001070658; NP_001070660; NP_001070661; NP_001317972; NP_001317973;
	NP_001317974; NP_031406; NP_666106; NP_001364439; NP_001364440; NP_001364441; NP_001364442
	Wikidata
View/Edit Human	View/Edit Mouse

Abl interactor 1 also known as Abelson interactor 1 (Abi-1) is a protein that in humans is encoded by the ABI1 gene.^[5]^[6]

Function[]

Abl interactor 1 has been found to form a complex with EPS8 and SOS1, and is thought to be involved in the transduction of signals from Ras to Rac. In addition, the encoded protein may play a role in the regulation of EGF-induced Erk pathway activation as well as cytoskeletal reorganization and EGFR signaling. Several transcript variants encoding multiple isoforms have been found for this gene.^[7]

Abi1 is adaptor protein. It interacts with c-Abl and WAVE2 which is an actin polymerization regulator. It is known that Abi1 enhances the phosphorylation of WAVE2 by c-Abl. The phosphorylation of c-Abl promotes actin polymerization. Furthermore, Abi1 is a component of the WAVE complex. Some research has shown that knockdown of Abi1 by siRNA promoted degradation of WAVE complex proteins.^{[citation needed]}

Interactions[]

ABI1 has been shown to interact with

ENAH,^[8] NCKAP1,^[9] EPS8,^[6]^[8]^[9]^[10]^[11] and SOS1.^[12]

References[]

^ Jump up to: ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000136754 - Ensembl, May 2017
^ Jump up to: ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000058835 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ziemnicka-Kotula D, Xu J, Gu H, Potempska A, Kim KS, Jenkins EC, Trenkner E, Kotula L (Jul 1998). "Identification of a candidate human spectrin Src homology 3 domain-binding protein suggests a general mechanism of association of tyrosine kinases with the spectrin-based membrane skeleton". J Biol Chem. 273 (22): 13681–92. doi:10.1074/jbc.273.22.13681. PMID 9593709.
^ Jump up to: ^a ^b Biesova Z, Piccoli C, Wong WT (Feb 1997). "Isolation and characterization of e3B1, an eps8 binding protein that regulates cell growth". Oncogene. 14 (2): 233–41. doi:10.1038/sj.onc.1200822. PMID 9010225.
^ "Entrez Gene: ABI1 abl-interactor 1".
^ Jump up to: ^a ^b Tani K, Sato S, Sukezane T, Kojima H, Hirose H, Hanafusa H, Shishido T (June 2003). "Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian enabled (Mena) by c-Abl kinase". J. Biol. Chem. 278 (24): 21685–92. doi:10.1074/jbc.M301447200. PMID 12672821.
^ Jump up to: ^a ^b Yamamoto A, Suzuki T, Sakaki Y (June 2001). "Isolation of hNap1BP which interacts with human Nap1 (NCKAP1) whose expression is down-regulated in Alzheimer's disease". Gene. 271 (2): 159–69. doi:10.1016/S0378-1119(01)00521-2. PMID 11418237.
^ Offenhäuser N, Borgonovo A, Disanza A, Romano P, Ponzanelli I, Iannolo G, Di Fiore PP, Scita G (January 2004). "The eps8 Family of Proteins Links Growth Factor Stimulation to Actin Reorganization Generating Functional Redundancy in the Ras/Rac Pathway". Mol. Biol. Cell. 15 (1): 91–8. doi:10.1091/mbc.E03-06-0427. PMC 307530. PMID 14565974.
^ Lanzetti L, Rybin V, Malabarba MG, Christoforidis S, Scita G, Zerial M, Di Fiore PP (November 2000). "The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5". Nature. 408 (6810): 374–7. Bibcode:2000Natur.408..374L. doi:10.1038/35042605. PMID 11099046. S2CID 4405293.
^ Scita G, Nordstrom J, Carbone R, Tenca P, Giardina G, Gutkind S, Bjarnegård M, Betsholtz C, Di Fiore PP (September 1999). "EPS8 and E3B1 transduce signals from Ras to Rac". Nature. 401 (6750): 290–3. Bibcode:1999Natur.401..290S. doi:10.1038/45822. PMID 10499589. S2CID 205045006.

External links[]

ABI1 human gene location in the UCSC Genome Browser.
ABI1 human gene details in the UCSC Genome Browser.

This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by .

[refGRCh38Ensembl-1] Jump up to: ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000136754 - Ensembl, May 2017

[refGRCm38Ensembl-2] Jump up to: ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000058835 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9593709-5] Ziemnicka-Kotula D, Xu J, Gu H, Potempska A, Kim KS, Jenkins EC, Trenkner E, Kotula L (Jul 1998). "Identification of a candidate human spectrin Src homology 3 domain-binding protein suggests a general mechanism of association of tyrosine kinases with the spectrin-based membrane skeleton". J Biol Chem. 273 (22): 13681–92. doi:10.1074/jbc.273.22.13681. PMID 9593709.

[pmid9010225-6] Jump up to: ^a ^b Biesova Z, Piccoli C, Wong WT (Feb 1997). "Isolation and characterization of e3B1, an eps8 binding protein that regulates cell growth". Oncogene. 14 (2): 233–41. doi:10.1038/sj.onc.1200822. PMID 9010225.

[entrez-7] "Entrez Gene: ABI1 abl-interactor 1".

[pmid12672821-8] Jump up to: ^a ^b Tani K, Sato S, Sukezane T, Kojima H, Hirose H, Hanafusa H, Shishido T (June 2003). "Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian enabled (Mena) by c-Abl kinase". J. Biol. Chem. 278 (24): 21685–92. doi:10.1074/jbc.M301447200. PMID 12672821.

[pmid11418237-9] Jump up to: ^a ^b Yamamoto A, Suzuki T, Sakaki Y (June 2001). "Isolation of hNap1BP which interacts with human Nap1 (NCKAP1) whose expression is down-regulated in Alzheimer's disease". Gene. 271 (2): 159–69. doi:10.1016/S0378-1119(01)00521-2. PMID 11418237.

[pmid14565974-10] Offenhäuser N, Borgonovo A, Disanza A, Romano P, Ponzanelli I, Iannolo G, Di Fiore PP, Scita G (January 2004). "The eps8 Family of Proteins Links Growth Factor Stimulation to Actin Reorganization Generating Functional Redundancy in the Ras/Rac Pathway". Mol. Biol. Cell. 15 (1): 91–8. doi:10.1091/mbc.E03-06-0427. PMC 307530. PMID 14565974.

[pmid11099046-11] Lanzetti L, Rybin V, Malabarba MG, Christoforidis S, Scita G, Zerial M, Di Fiore PP (November 2000). "The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5". Nature. 408 (6810): 374–7. Bibcode:2000Natur.408..374L. doi:10.1038/35042605. PMID 11099046. S2CID 4405293.

[pmid10499589-12] Scita G, Nordstrom J, Carbone R, Tenca P, Giardina G, Gutkind S, Bjarnegård M, Betsholtz C, Di Fiore PP (September 1999). "EPS8 and E3B1 transduce signals from Ras to Rac". Nature. 401 (6750): 290–3. Bibcode:1999Natur.401..290S. doi:10.1038/45822. PMID 10499589. S2CID 205045006.

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ABI1

Contents

Function[]

Interactions[]

References[]

Further reading[]

External links[]