Acylphosphatase can hydrolyze the phosphoenzyme intermediate of different membrane pumps, particularly the Ca2+/Mg2+-ATPase from sarcoplasmic reticulum of skeletal muscle. Two isoenzymes have been isolated, called muscle acylphosphatase and erythrocyte acylphosphatase on the basis of their tissue localization. This gene encodes the muscle-type isoform (MT). An increase of the MT isoform is associated with muscle differentiation.[6]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Modesti A, Raugei G, Taddei N, Marzocchini R, Vecchi M, Camici G, Manao G, Ramponi G (Dec 1993). "Chemical synthesis and expression of a gene coding for human muscle acylphosphatase". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1216 (3): 369–74. doi:10.1016/0167-4781(93)90003-v. PMID8268218.
Calamai M, Canale C, Relini A, Stefani M, Chiti F, Dobson CM (Feb 2005). "Reversal of protein aggregation provides evidence for multiple aggregated States". Journal of Molecular Biology. 346 (2): 603–616. doi:10.1016/j.jmb.2004.11.067. PMID15670608.
Chiti F, Taddei N, Baroni F, Capanni C, Stefani M, Ramponi G, Dobson CM (Feb 2002). "Kinetic partitioning of protein folding and aggregation". Nature Structural Biology. 9 (2): 137–143. doi:10.1038/nsb752. PMID11799398. S2CID22724295.
Chiti F, Taddei N, White PM, Bucciantini M, Magherini F, Stefani M, Dobson CM (Nov 1999). "Mutational analysis of acylphosphatase suggests the importance of topology and contact order in protein folding". Nature Structural Biology. 6 (11): 1005–1009. doi:10.1038/14890. PMID10542090. S2CID3124119.
Fiaschi T, Marzocchini R, Raugei G, Veggi D, Chiarugi P, Ramponi G (Nov 1997). "The 5'-untranslated region of the human muscle acylphosphatase mRNA has an inhibitory effect on protein expression". FEBS Letters. 417 (1): 130–134. doi:10.1016/S0014-5793(97)01270-2. PMID9395090. S2CID23901221.
Chiarugi P, Degl'Innocenti D, Raugei G, Fiaschi T, Ramponi G (Feb 1997). "Differential migration of acylphosphatase isoenzymes from cytoplasm to nucleus during apoptotic cell death". Biochemical and Biophysical Research Communications. 231 (3): 717–721. doi:10.1006/bbrc.1997.6176. PMID9070879.
Manao G, Camici G, Modesti A, Liguri G, Berti A, Stefani M, Cappugi G, Ramponi G (Dec 1984). "Human skeletal muscle acylphosphatase: the primary structure". Molecular Biology & Medicine. 2 (6): 369–78. PMID6100723.
Liguri G, Camici G, Manao G, Cappugi G, Nassi P, Modesti A, Ramponi G (Dec 1986). "A new acylphosphatase isoenzyme from human erythrocytes: purification, characterization, and primary structure". Biochemistry. 25 (24): 8089–8094. doi:10.1021/bi00372a044. PMID3026468.
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1aps: THREE-DIMENSIONAL STRUCTURE OF ACYLPHOSPHATASE. REFINEMENT AND STRUCTURE ANALYSIS
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