ADE model

An ADE model is a genetic model for twin studies which includes dominance genetic effects.^[1] Biometrical genetic modeling of twin or other family data can be used to decompose the variance of an observed response or phenotype into genetic and environmental components. Convenient parametrizations requiring few random effects allow such models to be estimated using widely available software for linear mixed models (continuous phenotypes) or generalized linear mixed models (categorical phenotypes).

A stands for additive genetic effects, D for non-additive genetic (or dominance) effects, and E for nonshared environment effects.^[2]

References[]

^ Locatelli I; et al. (2004). "The heritability of breast cancer: a Bayesian correlated frailty model applied to Swedish twins data". Twin Research. 7 (2): 182–191. doi:10.1375/136905204323016168. PMID 15169603.
^ Douglas A. Raynor et al. (2002). "Covariation of Psychosocial Characteristics Associated With Cardiovascular Disease: Genetic and Environmental Influences".

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[1] Locatelli I; et al. (2004). "The heritability of breast cancer: a Bayesian correlated frailty model applied to Swedish twins data". Twin Research. 7 (2): 182–191. doi:10.1375/136905204323016168. PMID 15169603.

[2] Douglas A. Raynor et al. (2002). "Covariation of Psychosocial Characteristics Associated With Cardiovascular Disease: Genetic and Environmental Influences".

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ADE model

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