Rho GTPase activating protein 25 is a protein that in humans is encoded by the ARHGAP25 gene .[5] KAIA0053 .[5] Rho GTPase -modulating proteins that are implicated in actin remodeling, cell polarity , and cell migration .[6]
Model organisms [ ] Model organisms have been used in the study of ARHGAP25 function. A conditional knockout mouse line, called Arhgap25tm1a(KOMP)Wtsi [13] [14] International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[15] [16] [17]
Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[11] [18] homozygous -mutant mice and one significant abnormality was observed: abnormal retina morphology and pigmentation.[11]
References [ ]
^ a b c GRCh38: Ensembl release 89: ENSG00000163219 - Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030047 - Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b "Rho GTPase activating protein 25" . Retrieved 2011-12-05 .^ Katoh M, Katoh M (August 2004). "Identification and characterization of ARHGAP24 and ARHGAP25 genes in silico". International Journal of Molecular Medicine . 14 (2): 333–8. doi :10.3892/ijmm.14.2.333 . PMID 15254788 . ^ "Eye morphology data for Arhgap25" . Wellcome Trust Sanger Institute.^ "Clinical chemistry data for Arhgap25" . Wellcome Trust Sanger Institute.^ "Salmonella infection data for Arhgap25" . Wellcome Trust Sanger Institute.^ "Citrobacter infection data for Arhgap25" . Wellcome Trust Sanger Institute.^ a b c Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica . 88 : 925–7. doi :10.1111/j.1755-3768.2010.4142.x . S2CID 85911512 . ^ Mouse Resources Portal , Wellcome Trust Sanger Institute.^ "International Knockout Mouse Consortium" .^ "Mouse Genome Informatics" .^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (June 2011). "A conditional knockout resource for the genome-wide study of mouse gene function" . Nature . 474 (7351): 337–42. doi :10.1038/nature10163 . PMC 3572410 PMID 21677750 . ^ Dolgin E (June 2011). "Mouse library set to be knockout" . Nature . 474 (7351): 262–3. doi :10.1038/474262a PMID 21677718 . ^ Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons" . Cell . 128 (1): 9–13. doi :10.1016/j.cell.2006.12.018 PMID 17218247 . S2CID 18872015 . ^ van der Weyden L, White JK, Adams DJ, Logan DW (June 2011). "The mouse genetics toolkit: revealing function and mechanism" . Genome Biology . 12 (6): 224. doi :10.1186/gb-2011-12-6-224 . PMC 3218837 PMID 21722353 .
Further reading [ ]
Takefuji M, Asano H, Mori K, Amano M, Kato K, Watanabe T, Morita Y, Katsumi A, Itoh T, Takenawa T, Hirashiki A, Izawa H, Nagata K, Hirayama H, Takatsu F, Naoe T, Yokota M, Kaibuchi K (January 2010). "Mutation of ARHGAP9 in patients with coronary spastic angina" . Journal of Human Genetics . 55 (1): 42–9. doi :10.1038/jhg.2009.120 PMID 19911011 . Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (1994). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1" . DNA Research . 1 (5): 223–9. doi :10.1093/dnares/1.5.223 PMID 7584044 .
