ARPC1A

ARPC1A
Identifiers
Aliases	ARPC1A, Arc40, HEL-68, SOP2Hs, SOP2L, HEL-S-307, actin related protein 2/3 complex subunit 1A
External IDs	OMIM: 604220 MGI: 1928896 HomoloGene: 4675 GeneCards: ARPC1A
Gene location (Human)
Chr.	Chromosome 7 (human)
End	99,366,262 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	145,045,571 bp
RNA expression pattern
	Top expressed in
	hypothalamus; ; Brodmann area 9; ; amygdala; ; hippocampus proper; ; nucleus accumbens;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	actin binding; actin filament binding;
Cellular component	cytoplasm; cytosol; Arp2/3 protein complex; extracellular exosome; cytoskeleton; actin cytoskeleton; muscle cell projection membrane; nucleus; site of double-strand break;
Biological process	ephrin receptor signaling pathway; regulation of actin filament polymerization; actin cytoskeleton organization; Fc-gamma receptor signaling pathway involved in phagocytosis; Arp2/3 complex-mediated actin nucleation; membrane organization;
	Sources:Amigo / QuickGO
Orthologs
	10552
	56443
	ENSG00000241685
	ENSMUSG00000029621
	Q92747
	Q9R0Q6
	NM_006409; NM_001190996
	NM_019767
	NP_001177925; NP_006400
	NP_062741
	Wikidata
View/Edit Human	View/Edit Mouse

Actin-related protein 2/3 complex subunit 1A is a protein that in humans is encoded by the ARPC1A gene.^[5]^[6]^[7]

This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1B. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages.^[7]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000241685 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029621 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Balasubramanian MK, Feoktistova A, McCollum D, Gould KL (Jan 1997). "Fission yeast Sop2p: a novel and evolutionarily conserved protein that interacts with Arp3p and modulates profilin function". EMBO J. 15 (23): 6426–37. doi:10.1002/j.1460-2075.1996.tb01034.x. PMC 452468. PMID 8978670.
^ Welch MD, DePace AH, Verma S, Iwamatsu A, Mitchison TJ (Aug 1997). "The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly". J Cell Biol. 138 (2): 375–84. doi:10.1083/jcb.138.2.375. PMC 2138188. PMID 9230079.
^ ^a ^b "Entrez Gene: ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa".

External links[]

Human ARPC1A genome location and ARPC1A gene details page in the UCSC Genome Browser.

Further reading[]

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Machesky LM, Reeves E, Wientjes F, et al. (1998). "Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins". Biochem. J. 328 (1): 105–12. doi:10.1042/bj3280105. PMC 1218893. PMID 9359840.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by .

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000241685 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029621 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8978670-5] Balasubramanian MK, Feoktistova A, McCollum D, Gould KL (Jan 1997). "Fission yeast Sop2p: a novel and evolutionarily conserved protein that interacts with Arp3p and modulates profilin function". EMBO J. 15 (23): 6426–37. doi:10.1002/j.1460-2075.1996.tb01034.x. PMC 452468. PMID 8978670.

[pmid9230079-6] Welch MD, DePace AH, Verma S, Iwamatsu A, Mitchison TJ (Aug 1997). "The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly". J Cell Biol. 138 (2): 375–84. doi:10.1083/jcb.138.2.375. PMC 2138188. PMID 9230079.

[entrez-7] "Entrez Gene: ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa".

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