This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that facilitates branching of actin filaments in cells. Isoforms of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages.[6] Indeed, it has recently been shown that variants of the Arp2/3 complex differ in their ability to promote actin assembly, with complexes containing ARPC1B and ARPC5L being better at this than those containing ARPC1A and ARPC5.[7] The differing functions of ARPC1A and ARPC1B are also evident in the recent discovery of patients with severe or total ARPC1B deficiency, who have platelet and immune system abnormalities yet survive, possibly due to a compensatory up-regulation of ARPC1A expression.[8]
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Robinson RC, Turbedsky K, Kaiser DA, Marchand JB, Higgs HN, Choe S, Pollard TD (Nov 2001). "Crystal structure of Arp2/3 complex". Science. 294 (5547): 1679–84. doi:10.1126/science.1066333. PMID11721045. S2CID18088124.
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Overview of all the structural information available in the PDB for UniProt: Q58CQ2 (Bovine Actin-related protein 2/3 complex subunit 1B) at the PDBe-KB.
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PDB gallery
1k8k: Crystal Structure of Arp2/3 Complex
1tyq: Crystal structure of Arp2/3 complex with bound ATP and calcium
1u2v: Crystal structure of Arp2/3 complex with bound ADP and calcium
2p9i: Crystal Structure of bovine Arp2/3 Complex co-crystallized with ADP and crosslinked with gluteraldehyde
2p9k: Crystal structure of bovine Arp2/3 complex co-crystallized with ATP and crosslinked with glutaraldehyde
2p9l: Crystal Structure of bovine Arp2/3 complex
2p9n: Crystal Structure of bovine Arp2/3 complex co-crystallized with ADP
2p9p: Crystal Structure of bovine Arp2/3 complex co-crystallized with ADP
2p9s: Structure of bovine Arp2/3 complex co-crystallized with ATP/Mg2+
2p9u: Crystal structure of bovine Arp2/3 complex co-crystallized with AMP-PNP and calcium
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