ATG4D
The human ATG4D gene encodes the protein Autophagy related 4D, cysteine peptidase.[5]
Function[]
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed.
This gene belongs to the autophagy-related protein 4 (Atg4) family of C54 endopeptidases. Members of this family encode proteins that play a role in the biogenesis of autophagosomes, which sequester the cytosol and organelles for degradation by lysosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
References[]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000130734 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002820 - Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Autophagy related 4D, cysteine peptidase".
Further reading[]
- Betin VM, MacVicar TD, Parsons SF, Anstee DJ, Lane JD (April 2012). "A cryptic mitochondrial targeting motif in Atg4D links caspase cleavage with mitochondrial import and oxidative stress". Autophagy. 8 (4): 664–76. doi:10.4161/auto.19227. PMC 3405841. PMID 22441018.
- Betin VM, Lane JD (July 2009). "Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis". Journal of Cell Science. 122 (Pt 14): 2554–66. doi:10.1242/jcs.046250. PMC 2704886. PMID 19549685.
- Mariño G, Uría JA, Puente XS, Quesada V, Bordallo J, López-Otín C (February 2003). "Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy". The Journal of Biological Chemistry. 278 (6): 3671–8. doi:10.1074/jbc.M208247200. PMID 12446702.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
- Genes on human chromosome 19
- Human chromosome 19 gene stubs
- Human proteins