ATP5H

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

ATP synthase D chain, mitochondrial
ATP synthase D chain, mitochondrial
Identifiers
Symbol	ATP5H
Pfam	PF05873
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

ATP5PD
Identifiers
Aliases	ATP5PD, ATPQ, ATP synthase, H+ transporting, mitochondrial Fo complex subunit D, ATP5H, ATP synthase peripheral stalk subunit d, APT5H
External IDs	OMIM: 618121 MGI: 1918929 HomoloGene: 130552 GeneCards: ATP5PD
Gene location (Human)
Chr.	Chromosome 17 (human)
End	75,046,985 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	115,310,788 bp
RNA expression pattern
	Top expressed in
	left ventricle; ; heart; ; myocardium; ; right ventricle; ; biceps brachii; ; caudate nucleus; ; atrium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ATPase activity; GO:0022891 transmembrane transporter activity; proton transmembrane transporter activity; proton-transporting ATP synthase activity, rotational mechanism; GO:0001948 protein binding; GO:0032403 protein-containing complex binding;
Cellular component	mitochondrial inner membrane; mitochondrial proton-transporting ATP synthase complex, coupling factor F(o); mitochondrial proton-transporting ATP synthase complex; mitochondrion; extracellular exosome; membrane; nucleoplasm; proton-transporting ATP synthase complex, coupling factor F(o); mitochondrial proton-transporting ATP synthase, stator stalk; cytosol;
Biological process	mitochondrial ATP synthesis coupled proton transport; ion transport; ATP synthesis coupled proton transport; ATP biosynthetic process; cristae formation; transport; ATP metabolic process; cellular response to peptide;
	Sources:Amigo / QuickGO
Orthologs
	10476
	71679
	ENSG00000167863
	ENSMUSG00000034566
	O75947
	Q9DCX2
	NM_006356; NM_001003785
	NM_027862
	NP_001003785; NP_006347
	NP_082138
	Wikidata
View/Edit Human	View/Edit Mouse

The human gene ATP5PD encodes subunit d of the peripheral stalk part of the enzyme mitochondrial ATP synthase.^[5]^[6]

Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F₁, and the membrane-spanning component, F₀, which comprises the proton channel. The F₁ complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The F_o seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the d subunit of the F_o complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. In addition, three pseudogenes are located on chromosomes 9, 12 and 15.^[6]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000167863 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034566 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
^ ^a ^b "Entrez Gene: ATP5PD ATP synthase peripheral stalk subunit d".

External links[]

Human ATP5PD genome location and ATP5PD gene details page in the UCSC Genome Browser.

Further reading[]

Kinosita K, Yasuda R, Noji H (2003). "F1-ATPase: a highly efficient rotary ATP machine". Essays Biochem. 35: 3–18. doi:10.1042/bse0350003. PMID 12471886.
Oster G, Wang H (2003). "Rotary protein motors". Trends Cell Biol. 13 (3): 114–21. doi:10.1016/S0962-8924(03)00004-7. PMID 12628343.
Leyva JA, Bianchet MA, Amzel LM (2003). "Understanding ATP synthesis: structure and mechanism of the F1-ATPase (Review)". Mol. Membr. Biol. 20 (1): 27–33. doi:10.1080/0968768031000066532. PMID 12745923. S2CID 218895820.
Higuti T, Kuroiwa K, Miyazaki S, et al. (1994). "The complete amino acid sequence of subunit d of rat liver mitochondrial H(+)-ATP synthase". J. Biochem. 114 (5): 714–7. doi:10.1093/oxfordjournals.jbchem.a124242. PMID 7509337.
Elston T, Wang H, Oster G (1998). "Energy transduction in ATP synthase". Nature. 391 (6666): 510–3. doi:10.1038/35185. PMID 9461222. S2CID 4406161.
Wang H, Oster G (1998). "Energy transduction in the F1 motor of ATP synthase". Nature. 396 (6708): 279–82. doi:10.1038/24409. PMID 9834036. S2CID 4424498.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Cross RL (2004). "Molecular motors: turning the ATP motor". Nature. 427 (6973): 407–8. doi:10.1038/427407b. PMID 14749816. S2CID 52819856.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by .

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000167863 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034566 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11042152-5] Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.

[entrez-6] "Entrez Gene: ATP5PD ATP synthase peripheral stalk subunit d".

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