ATP6V1G3

ATP6V1G3
Identifiers
Aliases	ATP6V1G3, ATP6G3, Vma10, ATPase H+ transporting V1 subunit G3
External IDs	OMIM: 618071 MGI: 2450548 HomoloGene: 13630 GeneCards: ATP6V1G3
Gene location (Human)
Chr.	Chromosome 1 (human)
End	198,540,945 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	138,217,200 bp
RNA expression pattern
	Top expressed in
	kidney; ; renal cortex; ; renal medulla; ; corpus epididymis; ; seminal vesicula;
	More reference expression data
	n/a
Gene ontology
Molecular function	ATPase binding; GO:0036442 P-type proton-exporting transporter activity; ATPase-coupled transmembrane transporter activity;
Cellular component	cytosol; plasma membrane; vacuolar proton-transporting V-type ATPase complex;
Biological process	proton transmembrane transport; insulin receptor signaling pathway; ion transmembrane transport; ion transport; transferrin transport; phagosome acidification;
	Sources:Amigo / QuickGO
Orthologs
	127124
	338375
	ENSG00000151418; ENSG00000263014
	ENSMUSG00000026394
	Q96LB4
	Q8BMC1
NM_133262; NM_133326; NM_001320218; NM_001376861; NM_001376862;
	NM_001376863
	NM_177397
NP_001307147; NP_573569; NP_579872; NP_001363790; NP_001363791;
	NP_001363792
	NP_796371
	Wikidata
View/Edit Human	View/Edit Mouse

V-type proton ATPase subunit G 3 is an enzyme that in humans is encoded by the ATP6V1G3 gene.^[5]^[6]

Function[]

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'' and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three G subunit proteins. Transcript variants encoding different isoforms have been found for this gene.^[6]

References[]

^ ^a ^b ^c ENSG00000263014 GRCh38: Ensembl release 89: ENSG00000151418, ENSG00000263014 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026394 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Stevens TH, Forgac M (Feb 1998). "Structure, function and regulation of the vacuolar (H+)-ATPase". Annual Review of Cell and Developmental Biology. 13: 779–808. doi:10.1146/annurev.cellbio.13.1.779. PMID 9442887.
^ ^a ^b "Entrez Gene: ATP6V1G3 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3".

External links[]

Human ATP6V1G3 genome location and ATP6V1G3 gene details page in the UCSC Genome Browser.

Further reading[]

Finbow ME, Harrison MA (Jun 1997). "The vacuolar H+-ATPase: a universal proton pump of eukaryotes". The Biochemical Journal. 324 (Pt 3): 697–712. doi:10.1042/bj3240697. PMC 1218484. PMID 9210392.
Nelson N, Harvey WR (Apr 1999). "Vacuolar and plasma membrane proton-adenosinetriphosphatases". Physiological Reviews. 79 (2): 361–85. doi:10.1152/physrev.1999.79.2.361. PMID 10221984.
Forgac M (May 1999). "Structure and properties of the vacuolar (H+)-ATPases". The Journal of Biological Chemistry. 274 (19): 12951–4. doi:10.1074/jbc.274.19.12951. PMID 10224039.
Kane PM (Feb 1999). "Introduction: V-ATPases 1992-1998". Journal of Bioenergetics and Biomembranes. 31 (1): 3–5. doi:10.1023/A:1001884227654. PMID 10340843.
Wieczorek H, Brown D, Grinstein S, Ehrenfeld J, Harvey WR (Aug 1999). "Animal plasma membrane energization by proton-motive V-ATPases". BioEssays. 21 (8): 637–48. doi:10.1002/(SICI)1521-1878(199908)21:8<637::AID-BIES3>3.0.CO;2-W. PMID 10440860.
Nishi T, Forgac M (Feb 2002). "The vacuolar (H+)-ATPases--nature's most versatile proton pumps". Nature Reviews Molecular Cell Biology. 3 (2): 94–103. doi:10.1038/nrm729. PMID 11836511. S2CID 21122465.
Kawasaki-Nishi S, Nishi T, Forgac M (Jun 2003). "Proton translocation driven by ATP hydrolysis in V-ATPases". FEBS Letters. 545 (1): 76–85. doi:10.1016/S0014-5793(03)00396-X. PMID 12788495. S2CID 10507213.
Morel N (Oct 2003). "Neurotransmitter release: the dark side of the vacuolar-H+ATPase". Biology of the Cell. 95 (7): 453–7. doi:10.1016/S0248-4900(03)00075-3. PMID 14597263.
Brown D, Lui B, Gluck S, Sabolić I (Oct 1992). "A plasma membrane proton ATPase in specialized cells of rat epididymis". The American Journal of Physiology. 263 (4 Pt 1): C913–6. doi:10.1152/ajpcell.1992.263.4.C913. PMID 1415677.
Smith AN, Borthwick KJ, Karet FE (Sep 2002). "Molecular cloning and characterization of novel tissue-specific isoforms of the human vacuolar H(+)-ATPase C, G and d subunits, and their evaluation in autosomal recessive distal renal tubular acidosis". Gene. 297 (1–2): 169–77. doi:10.1016/S0378-1119(02)00884-3. PMID 12384298.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by .

[refGRCh38Ensembl-1] ENSG00000263014 GRCh38: Ensembl release 89: ENSG00000151418, ENSG00000263014 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026394 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9442887-5] Stevens TH, Forgac M (Feb 1998). "Structure, function and regulation of the vacuolar (H+)-ATPase". Annual Review of Cell and Developmental Biology. 13: 779–808. doi:10.1146/annurev.cellbio.13.1.779. PMID 9442887.

[entrez-6] "Entrez Gene: ATP6V1G3 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3".

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