Acetylcorynoline

Acetylcorynoline
Names
	Preferred IUPAC name (5bR,6S,12bR)-5b,13-Dimethyl-5b,6,7,12b,13,14-hexahydro-2H,10H-[1,3]benzodioxolo[5,6-c][1,3]dioxolo[4,5-i]phenanthridin-6-yl acetate
Identifiers
CAS Number	18797-80-3;
3D model (JSmol)	Interactive image;
ChemSpider	154160;
ECHA InfoCard	100.208.690
PubChem CID	177015;
CompTox Dashboard (EPA)	DTXSID70172127 ;
	InChI InChI=1S/C23H23NO6/c1-12(25)30-20-7-13-6-18-19(28-10-27-18)8-14(13)22-23(20,2)16-4-5-17-21(29-11-26-17)15(16)9-24(22)3/h4-6,8,20,22H,7,9-11H2,1-3H3/t20-,22+,23-/m0/s1 Key: PUHCFWFODBLSAP-WWNPGLIZSA-N; InChI=1/C23H23NO6/c1-12(25)30-20-7-13-6-18-19(28-10-27-18)8-14(13)22-23(20,2)16-4-5-17-21(29-11-26-17)15(16)9-24(22)3/h4-6,8,20,22H,7,9-11H2,1-3H3/t20-,22+,23-/m0/s1 Key: PUHCFWFODBLSAP-WWNPGLIZBS;
	SMILES CC(=O)O[C@H]1CC2=CC3=C(C=C2[C@@H]4[C@]1(C5=C(CN4C)C6=C(C=C5)OCO6)C)OCO3;
Properties
Chemical formula	C23H23NO6
Molar mass	409.438 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	Infobox references

Acetylcorynoline is a bio-active isolate of Corydalis ambigua. It inhibits the maturing of bone marrow-derived dendritic cells in mice. However, it is only cytotoxic in amounts of greater than 20 μM.^[1]

References[]

^ Fu, RH; Wang, YC; Liu, SP; Chu, CL; Tsai, RT; Ho, YC; Chang, WL; Chiu, SC; Harn, HJ; Shyu, WC; Lin, SZ (2013). Caldwell, Charles C (ed.). "Acetylcorynoline impairs the maturation of mouse bone marrow-derived dendritic cells via suppression of IκB kinase and mitogen-activated protein kinase activities". PLOS ONE. 8 (3): e58398. doi:10.1371/journal.pone.0058398. PMC 3589392. PMID 23472193.

External links[]

Protective action of corynoline, acetylcorynoline and protopine against experimental liver injury in mice

[1] Fu, RH; Wang, YC; Liu, SP; Chu, CL; Tsai, RT; Ho, YC; Chang, WL; Chiu, SC; Harn, HJ; Shyu, WC; Lin, SZ (2013). Caldwell, Charles C (ed.). "Acetylcorynoline impairs the maturation of mouse bone marrow-derived dendritic cells via suppression of IκB kinase and mitogen-activated protein kinase activities". PLOS ONE. 8 (3): e58398. doi:10.1371/journal.pone.0058398. PMC 3589392. PMID 23472193.

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