Aconiazide
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IUPAC name
2-[2-[(E)-(Pyridine-4-carbonylhydrazinylidene)methyl]phenoxy]acetic acid
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Other names
Isonicophen; Phenoxalid
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Identifiers | |
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Properties | |
C15H13N3O4 | |
Molar mass | 299.286 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
Infobox references | |
Aconiazide is an anti-tuberculosis medication. It is a prodrug of isoniazide that was developed and studied for its lower toxicity,[1][2] but it does not appear to be marketed anywhere in the world in 2021.
References[]
- ^ Hansen Jr, EB; Dooley, KL; Thompson Jr, HC (1995). "High-performance liquid chromatographic analysis of the antituberculosis drugs aconiazide and isoniazid". Journal of Chromatography B. 670 (2): 259–66. doi:10.1016/0378-4347(95)00176-x. PMID 8548016.
- ^ Peloquin, C. A.; James, G. T.; Craig, L. D.; Kim, M; McCarthy, E. A.; Iklé, D; Iseman, M. D. (1994). "Pharmacokinetic evaluation of aconiazide, a potentially less toxic isoniazid prodrug". Pharmacotherapy. 14 (4): 415–23. doi:10.1002/j.1875-9114.1994.tb02831.x (inactive 31 October 2021). PMID 7937278.CS1 maint: DOI inactive as of October 2021 (link)
Categories:
- Prodrugs
- Carboxylic acids
- Hydrazides
- Pyridines
- Antiinfective agent stubs