Altoqualine
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Preferred IUPAC name
(3S)-7-Amino-4,5,6-triethoxy-3-[(1R)-6,7,8-trimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl]-2-benzofuran-1(3H)-one | |
Other names
458 L
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Identifiers | |
3D model (JSmol)
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ChEMBL | |
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PubChem CID
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UNII | |
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Properties | |
C27H36N2O8 | |
Molar mass | 516.591 g·mol−1 |
Melting point | 144 °C (291 °F; 417 K)[1] |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
Infobox references | |
Altoqualine is an isoquinoline once studied for its potential use as an antihistamine and antiallergic,[1][2][3] but it was never a marketed drug. It is an inhibitor of histidine decarboxylase.[2]
References[]
- ^ a b C.R. Ganellin; David J. Triggle (Nov 21, 1996). Dictionary of Pharmacological Agents. 1–2. CRC Press. p. 58.
- ^ a b Lallouette P, Mordelet-Dambrine M, Treize G, N'Guyen VT, Dubois AM, Parrot JL (1981). "Pharmacological approach of a new isoquinoline derivative (458 L)". Agents and Actions. 11 (1–2): 41–43. doi:10.1007/BF01991453. PMID 7195643.
- ^ Bargnoux H, Kantelip JP, Bastide M, Duchene-Marullaz P, Boyer R, Lallouette P, Petit J, Berger JA (1990). "Pharmacokinetic study of a new benzyl-1 isoquinoline derivative (458 L) after oral administration in men". Thérapie. 45 (1): 7–11. PMID 1971461.
Categories:
- Benzylisoquinolines
- Antihistamines
- Histidine decarboxylase inhibitors
- Respiratory system drug stubs