Amonafide
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Trade names | Xanafide, Quinamed |
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Formula | C16H17N3O3 |
Molar mass | 299.330 g·mol−1 |
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Amonafide (originally AS1413) (INN, trade names Quinamed and Xanafide) is a drug that is being studied in the treatment of cancer. It belongs to a novel family of chemotherapeutic drugs called Naphthalimides and is a potential topoisomerase inhibitor and DNA intercalator.
It is being developed as an anti-cancer therapy by .[1]
As of 2008, it is in Phase III clinical trials. e.g. In March 2010 it is Phase III trial against secondary acute myeloid leukaemia (AML).[2] In June 2010, it gained an FDA Fast Track Status for the treatment of Secondary Acute Myeloid Leukaemia.
See also[]
References[]
- ^ http://www.genengnews.com/news/bnitem.aspx?name=78979622
- ^ http://clinicaltrials.gov/ct2/show/NCT00715637 "Phase III Randomized Study of Amonafide (AS1413) and Cytarabine Versus Daunorubicin and Cytarabine in Patients With Secondary Acute Myeloid Leukemia (AML)- the ACCEDE Study"
External links[]
- Amonafide entry in the public domain NCI Dictionary of Cancer Terms
- Clinical trials of amonafide at ClinicalTrials.gov
This article incorporates public domain material from the U.S. National Cancer Institute document: "Dictionary of Cancer Terms".
Categories:
- Drugs not assigned an ATC code
- Experimental cancer drugs
- Antineoplastic and immunomodulating drug stubs