Aphthovirus internal ribosome entry site (IRES)

Aphthovirus internal ribosome entry site (IRES)
Aphthovirus internal ribosome entry site (IRES)
	Predicted secondary structure and sequence conservation of IRES_Aptho
Identifiers
Symbol	IRES_Aptho
Alt. Symbols	Aptho_IRES
Rfam	RF00210
Other data
RNA type	Cis-reg; IRES
Domain(s)	Viruses
GO	GO:0043022
SO	SO:0000243
PDB structures	PDBe

This family represents the internal ribosome entry site (IRES) of the Picornaviruses.^[1] IRES elements allow cap and end-independent translation of mRNA in the host cell. The IRES achieves this by mediating the internal initiation of translation by recruiting a ribosomal 43S pre-initiation complex directly to the initiation codon and eliminates the requirement for the eukaryotic initiation factor eIF4F.^[2]

References[]

^ Fernández-Miragall O, Martínez-Salas E (November 2003). "Structural organization of a viral IRES depends on the integrity of the GNRA motif" (PDF). RNA. 9 (11): 1333–1344. doi:10.1261/rna.5950603. PMC 1287055. PMID 14561883.
^ Kolupaeva VG, Pestova TV, Hellen CU (December 2000). "Ribosomal binding to the internal ribosomal entry site of classical swine fever virus". RNA. 6 (12): 1791–1807. doi:10.1017/S1355838200000662. PMC 1370049. PMID 11142379.

External links[]

Page for Aphthovirus internal ribosome entry site (IRES) at Rfam

This molecular or cell biology article is a stub. You can help Wikipedia by .

[1] Fernández-Miragall O, Martínez-Salas E (November 2003). "Structural organization of a viral IRES depends on the integrity of the GNRA motif" (PDF). RNA. 9 (11): 1333–1344. doi:10.1261/rna.5950603. PMC 1287055. PMID 14561883.

[2] Kolupaeva VG, Pestova TV, Hellen CU (December 2000). "Ribosomal binding to the internal ribosomal entry site of classical swine fever virus". RNA. 6 (12): 1791–1807. doi:10.1017/S1355838200000662. PMC 1370049. PMID 11142379.

[1]

[2]