Asialoglycoprotein receptor

asialoglycoprotein receptor 2
asialoglycoprotein receptor 2
Identifiers
Symbol	ASGR2
NCBI gene	433
HGNC	743
OMIM	108361
RefSeq	NM_080914
UniProt	P07307
Other data
Locus	Chr. 17 p
Structures
Search for
Structures	Swiss-model
Domains	InterPro

Search for
Structures	Swiss-model
Domains	InterPro

asialoglycoprotein receptor 1
asialoglycoprotein receptor 1
Identifiers
Symbol	ASGR1
NCBI gene	432
HGNC	742
OMIM	108360
RefSeq	NM_001671
UniProt	P07306
Other data
Locus	Chr. 17 p13-p11
Structures
Search for
Structures	Swiss-model
Domains	InterPro

The asialoglycoprotein receptors are lectins which bind asialoglycoprotein and glycoproteins from which a sialic acid has been removed to expose galactose residues. The receptors, which are located on liver cells, remove the target glycoproteins from circulation. The asialoglycoprotein receptor has been demonstrated to have high expression on the surface of hepatocytes [1], several human carcinoma cell lines[2] and liver cancers.[3] It is also weakly expressed by glandular cells of the gallbladder and the stomach. Lactobionic acid has been used as a targeting moiety for drug delivery to cells expressing asialoglycoprotein receptors.^[1]

References[]

^ Roggenbuck D, Mytilinaiou MG, Lapin SV, Reinhold D, Conrad K (December 2012). "Asialoglycoprotein receptor (ASGPR): a peculiar target of liver-specific autoimmunity". Auto- Immunity Highlights. 3 (3): 119–25. doi:10.1007/s13317-012-0041-4. PMC 4389076. PMID 26000135.

External links[]

Asialoglycoprotein+receptor at the US National Library of Medicine Medical Subject Headings (MeSH)

This biochemistry article is a stub. You can help Wikipedia by .

[1] Roggenbuck D, Mytilinaiou MG, Lapin SV, Reinhold D, Conrad K (December 2012). "Asialoglycoprotein receptor (ASGPR): a peculiar target of liver-specific autoimmunity". Auto- Immunity Highlights. 3 (3): 119–25. doi:10.1007/s13317-012-0041-4. PMC 4389076. PMID 26000135.

[1]