Asporin

ASPN
Identifiers
Aliases	ASPN, OS3, PLAP-1, PLAP1, SLRR1C, asporin, Asporin
External IDs	OMIM: 608135 MGI: 1913945 HomoloGene: 32357 GeneCards: ASPN
Gene location (Human)
Chr.	Chromosome 9 (human)
End	92,482,506 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	49,721,041 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; synovial joint; ; synovial membrane; ; periodontal fiber; ; connective tissue; ; thoracic aorta; ; myometrium; ; tendon; ; visceral pleura;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; protein kinase inhibitor activity; collagen binding; extracellular matrix structural constituent conferring compression resistance;
Cellular component	cytoplasm; GO:0005578 extracellular matrix; extracellular region; collagen-containing extracellular matrix;
Biological process	bone mineralization; biomineral tissue development; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of tooth mineralization; negative regulation of protein kinase activity; cytokine-mediated signaling pathway; negative regulation of receptor signaling pathway via JAK-STAT;
	Sources:Amigo / QuickGO
Orthologs
	54829
	66695
	ENSG00000106819
	ENSMUSG00000021388
	Q9BXN1
	Q99MQ4
	NM_017680; NM_001193335
	NM_001172481; NM_025711
	NP_001180264; NP_060150
	NP_001165952; NP_079987
	Wikidata
View/Edit Human	View/Edit Mouse

Asporin is a protein that in humans is encoded by the ASPN gene.^[5]

Function[]

ASPN belongs to a family of leucine-rich repeat (LRR) proteins associated with the cartilage matrix. The name asporin reflects the unique aspartate-rich N terminus and the overall similarity to decorin (MIM 125255) (Lorenzo et al., 2001).^[5]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000106819 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021388 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: ASPN asporin".

External links[]

Human ASPN genome location and ASPN gene details page in the UCSC Genome Browser.

Further reading[]

Lorenzo P, Aspberg A, Onnerfjord P, Bayliss MT, Neame PJ, Heinegard D (Apr 2001). "Identification and characterization of asporin. a novel member of the leucine-rich repeat protein family closely related to decorin and biglycan". The Journal of Biological Chemistry. 276 (15): 12201–11. doi:10.1074/jbc.M010932200. PMID 11152692.
Henry SP, Takanosu M, Boyd TC, Mayne PM, Eberspaecher H, Zhou W, de Crombrugghe B, Hook M, Mayne R (Apr 2001). "Expression pattern and gene characterization of asporin. a newly discovered member of the leucine-rich repeat protein family". The Journal of Biological Chemistry. 276 (15): 12212–21. doi:10.1074/jbc.M011290200. PMID 11152695.
Yamada S, Murakami S, Matoba R, Ozawa Y, Yokokoji T, Nakahira Y, Ikezawa K, Takayama S, Matsubara K, Okada H (Sep 2001). "Expression profile of active genes in human periodontal ligament and isolation of PLAP-1, a novel SLRP family gene". Gene. 275 (2): 279–86. doi:10.1016/S0378-1119(01)00683-7. PMID 11587855.
Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (Oct 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Kizawa H, Kou I, Iida A, Sudo A, Miyamoto Y, Fukuda A, Mabuchi A, Kotani A, Kawakami A, Yamamoto S, Uchida A, Nakamura K, Notoya K, Nakamura Y, Ikegawa S (Feb 2005). "An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis". Nature Genetics. 37 (2): 138–44. doi:10.1038/ng1496. PMID 15640800. S2CID 6771016.
Rodriguez-Lopez J, Pombo-Suarez M, Liz M, Gomez-Reino JJ, Gonzalez A (2006). "Lack of association of a variable number of aspartic acid residues in the asporin gene with osteoarthritis susceptibility: case-control studies in Spanish Caucasians". Arthritis Research & Therapy. 8 (3): R55. doi:10.1186/ar1920. PMC 1526645. PMID 16542493.
Yamada S, Ozawa Y, Tomoeda M, Matoba R, Matsubara K, Murakami S (May 2006). "Regulation of PLAP-1 expression in periodontal ligament cells". Journal of Dental Research. 85 (5): 447–51. doi:10.1177/154405910608500510. PMID 16632759. S2CID 40160016.
Jiang Q, Shi D, Yi L, Ikegawa S, Wang Y, Nakamura T, Qiao D, Liu C, Dai J (2007). "Replication of the association of the aspartic acid repeat polymorphism in the asporin gene with knee-osteoarthritis susceptibility in Han Chinese". Journal of Human Genetics. 51 (12): 1068–72. doi:10.1007/s10038-006-0065-6. PMID 17024313.
Nakamura T, Shi D, Tzetis M, Rodriguez-Lopez J, Miyamoto Y, Tsezou A, Gonzalez A, Jiang Q, Kamatani N, Loughlin J, Ikegawa S (Jul 2007). "Meta-analysis of association between the ASPN D-repeat and osteoarthritis". Human Molecular Genetics. 16 (14): 1676–81. doi:10.1093/hmg/ddm115. PMID 17517696.
Shi D, Nakamura T, Dai J, Yi L, Qin J, Chen D, Xu Z, Wang Y, Ikegawa S, Jiang Q (2007). "Association of the aspartic acid-repeat polymorphism in the asporin gene with age at onset of knee osteoarthritis in Han Chinese population". Journal of Human Genetics. 52 (8): 664–7. doi:10.1007/s10038-007-0166-x. PMID 17603749.
Kou I, Nakajima M, Ikegawa S (Nov 2007). "Expression and regulation of the osteoarthritis-associated protein asporin". The Journal of Biological Chemistry. 282 (44): 32193–9. doi:10.1074/jbc.M706262200. PMID 17804408.
Nakajima M, Kizawa H, Saitoh M, Kou I, Miyazono K, Ikegawa S (Nov 2007). "Mechanisms for asporin function and regulation in articular cartilage". The Journal of Biological Chemistry. 282 (44): 32185–92. doi:10.1074/jbc.M700522200. PMID 17827158.

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by .

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000106819 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021388 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: ASPN asporin".

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