B4GALNT2

B4GALNT2
Identifiers
Aliases	B4GALNT2, B4GALT, GALGT2, beta-1,4-N-acetyl-galactosaminyltransferase 2
External IDs	OMIM: 111730 MGI: 1342058 HomoloGene: 7329 GeneCards: B4GALNT2
Gene location (Human)
Chr.	Chromosome 17 (human)
End	49,176,840 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	95,805,717 bp
RNA expression pattern
	Top expressed in
	colon; ; stomach; ; transverse colon; ; kidney; ; small intestine; ; renal cortex; ; rectum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; hexosyltransferase activity; glycosyltransferase activity; acetylgalactosaminyltransferase activity;
Cellular component	integral component of membrane; integral component of Golgi membrane; Golgi apparatus; membrane; Golgi membrane;
Biological process	UDP-N-acetylglucosamine metabolic process; protein glycosylation; UDP-N-acetylgalactosamine metabolic process; lipid glycosylation; negative regulation of cell-cell adhesion; protein N-linked glycosylation via asparagine;
	Sources:Amigo / QuickGO
Orthologs
	124872
	14422
	ENSG00000167080
	ENSMUSG00000013418
	Q8NHY0
	Q09199
	NM_001159387; NM_001159388; NM_153446
	NM_008081
	NP_001152859; NP_001152860; NP_703147
	NP_032107
	Wikidata
View/Edit Human	View/Edit Mouse

Beta-1,4 N-acetylgalactosaminyltransferase 2 is an enzyme that in humans is encoded by the B4GALNT2 gene.^[5]^[6]^[7]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000167080 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000013418 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dohi T, Yuyama Y, Natori Y, Smith PL, Lowe JB, Oshima M (Sep 1996). "Detection of N-acetylgalactosaminyltransferase mRNA which determines expression of Sda blood group carbohydrate structure in human gastrointestinal mucosa and cancer". International Journal of Cancer. 67 (5): 626–31. doi:10.1002/(SICI)1097-0215(19960904)67:5<626::AID-IJC6>3.0.CO;2-W. PMID 8782649.
^ Montiel MD, Krzewinski-Recchi MA, Delannoy P, Harduin-Lepers A (Jul 2003). "Molecular cloning, gene organization and expression of the human UDP-GalNAc:Neu5Acalpha2-3Galbeta-R beta1,4-N-acetylgalactosaminyltransferase responsible for the biosynthesis of the blood group Sda/Cad antigen: evidence for an unusual extended cytoplasmic domain". The Biochemical Journal. 373 (Pt 2): 369–79. doi:10.1042/BJ20021892. PMC 1223490. PMID 12678917.
^ "Entrez Gene: B4GALNT2 beta-1,4-N-acetyl-galactosaminyl transferase 2".

External links[]

Human B4GALNT2 genome location and B4GALNT2 gene details page in the UCSC Genome Browser.

Further reading[]

Berger EG (Feb 2002). "Ectopic localizations of Golgi glycosyltransferases". Glycobiology. 12 (2): 29R–36R. doi:10.1093/glycob/12.2.29R. PMID 11886838.
Wang HR, Hsieh CY, Twu YC, Yu LC (Jan 2008). "Expression of the human Sd(a) beta-1,4-N-acetylgalactosaminyltransferase II gene is dependent on the promoter methylation status". Glycobiology. 18 (1): 104–13. doi:10.1093/glycob/cwm120. PMID 17965433.
Kawamura YI, Kawashima R, Fukunaga R, Hirai K, Toyama-Sorimachi N, Tokuhara M, Shimizu T, Dohi T (Jul 2005). "Introduction of Sd(a) carbohydrate antigen in gastrointestinal cancer cells eliminates selectin ligands and inhibits metastasis". Cancer Research. 65 (14): 6220–7. doi:10.1158/0008-5472.CAN-05-0639. PMID 16024623.
Lo Presti L, Cabuy E, Chiricolo M, Dall'Olio F (Nov 2003). "Molecular cloning of the human beta1,4 N-acetylgalactosaminyltransferase responsible for the biosynthesis of the Sd(a) histo-blood group antigen: the sequence predicts a very long cytoplasmic domain". Journal of Biochemistry. 134 (5): 675–82. doi:10.1093/jb/mvg192. PMID 14688233.
Piller F, Blanchard D, Huet M, Cartron JP (Jun 1986). "Identification of a alpha-NeuAc-(2----3)-beta-D-galactopyranosyl N-acetyl-beta-D-galactosaminyltransferase in human kidney". Carbohydrate Research. 149 (1): 171–84. doi:10.1016/S0008-6215(00)90376-8. PMID 2425965.
Li PT, Liao CJ, Wu WG, Yu LC, Chu ST (Jun 2011). "Progesterone-regulated B4galnt2 expression is a requirement for embryo implantation in mice". Fertility and Sterility. 95 (7): 2404–9, 2409.e1–3. doi:10.1016/j.fertnstert.2011.03.043. PMID 21481371.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by .

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000167080 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000013418 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8782649-5] Dohi T, Yuyama Y, Natori Y, Smith PL, Lowe JB, Oshima M (Sep 1996). "Detection of N-acetylgalactosaminyltransferase mRNA which determines expression of Sda blood group carbohydrate structure in human gastrointestinal mucosa and cancer". International Journal of Cancer. 67 (5): 626–31. doi:10.1002/(SICI)1097-0215(19960904)67:5<626::AID-IJC6>3.0.CO;2-W. PMID 8782649.

[pmid12678917-6] Montiel MD, Krzewinski-Recchi MA, Delannoy P, Harduin-Lepers A (Jul 2003). "Molecular cloning, gene organization and expression of the human UDP-GalNAc:Neu5Acalpha2-3Galbeta-R beta1,4-N-acetylgalactosaminyltransferase responsible for the biosynthesis of the blood group Sda/Cad antigen: evidence for an unusual extended cytoplasmic domain". The Biochemical Journal. 373 (Pt 2): 369–79. doi:10.1042/BJ20021892. PMC 1223490. PMID 12678917.

[entrez-7] "Entrez Gene: B4GALNT2 beta-1,4-N-acetyl-galactosaminyl transferase 2".

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