Biotin carboxyl carrier protein

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Biotin Carboxyl Carrier Protein (BCCP) refers to proteins containing a biotin attachment domain that carry biotin and carboxybiotin throughout the ATP-dependent carboxylation by biotin-dependent carboxylases. In the case of E. coli Acetyl-CoA carboxylase, the BCCP is a separate protein known as accB (P0ABD8). On the other hand, in Haloferax mediterranei Propionyl-CoA carboxylase, the BCCP pccA (I3R7G3) is fused with biotin carboxylase.

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