Bonnie Bassler
A major contributor to this article appears to have a close connection with its subject. (May 2021) |
Bonnie Bassler | |
---|---|
Born | Bonnie Lynn Bassler 1962 (age 58–59) |
Nationality | American |
Citizenship | United States |
Alma mater | University of California, Davis Johns Hopkins University |
Known for | Quorum sensing |
Spouse(s) | Todd Reichart |
Awards | Wiley Prize in Biomedical Science (2009) Richard Lounsbery Award (2011) Shaw Prize (2015) Pearl Meister Greengard Prize (2016) Foreign Member of the Royal Society[1] Genetics Society of America Medal (2020) |
Scientific career | |
Institutions | Princeton University |
Bonnie Lynn Bassler (born 1962)[2] is an American molecular biologist who has researched chemical communication between bacteria known as quorum sensing, and contributed to the idea that disruption of chemical signaling can be used as an antimicrobial therapy. She is the Squibb Professor in Molecular Biology and chair of the Department of Molecular Biology at Princeton University. She is a Howard Hughes Medical Institute Investigator and her research focuses on bacterial quorum sensing, which is the cell-to-cell communication in bacteria.[3]
She has received numerous awards for her research, including the Wiley Prize in Biomedical Sciences (2009), the Richard Lounsbery Award (2011), and the L’Oreal-UNESCO award (2012), a MacArthur Fellowship[4] (2002),[5] and the Pearl Meister Greengard Prize (2016).[6] She is a former president of the American Society for Microbiology, a member of the National Academy of Sciences, and a former six-year member of National Science Board.
Early life and education[]
Born in Chicago and raised in Danville, California,[7] Bassler was intellectually curious from a young age, as she enjoyed solving various logic puzzles. Bassler began her career in science "as a veterinarian’s assistant at the Miami Zoo and later at a local dog and cat clinic."[8] Bassler received a Bachelor of Science in biochemistry from the University of California, Davis. Despite her entry as a major in veterinary sciences, she preferred to focus on genetics and biochemistry. She stated that these subjects allowed her the "gateway to solving biological puzzles."[9] She began to work for UC Davis biochemistry and molecular medicine professor Frederic Troy. Troy's research focuses included bacterial carbohydrates and the relationship between the Epstein-Barr virus and cancer. At the time, the cancer project appealed to Bassler more than the research on bacteria, but Troy assigned her to the bacteria research project. Within this project, Bassler characterized an enzyme in E. coli which cleaved sugars from various membrane glycoproteins. Eventually, Bassler admired working with prokaryotes as she stated that "they're the perfect creatures to work on."[9]
Following her undergraduate research, Bassler received a Ph.D. in biochemistry from Johns Hopkins University.[10] She achieved key insights into the mechanism by which bacteria communicate,[11] known as quorum sensing. Her postdoctoral research was conducted at Agouron Institute in genetics for four years.[12] Here, she studied glow-in-the-dark bacteria that cause the oceanic light show. She used her previous knowledge and research to demonstrate that when there were enough cohorts to make effort, bacteria gave off light. In 1994, Bassler joined the Princeton faculty. She is currently the chair of the department of molecular biology and the Squibb Professor in molecular biology.[13] Following her postdoctoral research, the MacArthur Foundation awarded Bassler its fellowship in 2002, which recognized her for her immense contributions to the bacterial lexicon.
Research[]
Bassler has been conducting research for the past two decades. During her postdoctoral research, Bassler continued working with bacteria. Bassler was originally experimenting with genetic manipulation of bioluminescent genes in bacteria. She began doing research with V. harveyi bacteria and discovered that this bacteria had multiple molecules for quorum sensing. She found that these bacteria use quorum sensing to turn on and off a large number of genes in response to communications from other bacteria. These communications and responses allow bacteria of the same species and of different species to cooperate in a similar manner to multi-cellular organisms. She furthered this research by attempting to figure out how bacteria communicate. A series of experiments led to the discovery that boron binding is used as a co-factor. This element is found in abundance in the oceans where V. harveyi is found.[14]
Currently, she leads a lab in Princeton University that researches in Quorum Sensing: the process of cell-cell communication in Bacteria.[15] Bassler's discoveries are described as "opening new vistas in basic science, but also of practical significance."[16] As antibiotic resistance in human pathogens continues to be a significant challenge in research, Bassler's research contributed new and exciting strategies for treating bacterial disease. Bassler has received numerous awards, but most recently she was awarded the Gruber Genetics Prize. Within Bassler's lab, they focus on intra- and inter-species communication, self versus non-self recognition, information transferring, and population level cooperation. She focuses on five related research topics: How Bacteria Distinguish Self from Other: Ligand-Receptor Interactions, Dynamics: Small RNA Regulation of Quorum Sensing, Biofilms Under Flow and the Public Goods Dilemma, Manipulation of Quorum Sensing on Demand, and Micriblome Quorum Sensing and Inter-Kingdom Communication.[15]
Apart from her research on Bacteria, Bassler has also made major contributions to the science community. Some of her contributions include authoring a section in iBiology's New Online Textbook. This textbook is a free source for students in higher education and self-learners. Bassler's section is a narrative on Quorum Sensing and How Bacteria Communicate.[17] She hopes to make sure that everyone gets opportunities to learn and participate in science.
Awards and honors[]
- 2002 MacArthur Fellowship[4]
- 2004 Elected member of the American Association for the Advancement of Science[18]
- 2006 National Academy of Sciences[7]
- 2007 Fellow of the American Academy of Arts and Sciences[2]
- 2008 Special Recognition from the World Cultural Council[19]
- 2009 Wiley Prize in Biomedical Sciences[20][21]
- 2010 USA Science and Engineering Festival's Nifty Fifty Speakers, nominated by American Society for Microbiology[22]
- 2010–2016 National Science Board, nominated by President Barack Obama[23]
- 2011 Richard Lounsbery Award[24]
- 2011 L'Oréal-UNESCO For Women in Science Awards Laureate for North America[25]
- 2011 President of the American Society for Microbiology[26]
- 2012 Member in the American Philosophical Society[27]
- 2014 American Society for Microbiology EMD Millipore Alice C. Evans Award[28]
- 2014 Phi Beta Kappa Excellence in Teaching Award [29]
- 2015 Shaw Prize in Life Science and Medicine[30]
- 2016 The FASEB Excellence in Science Award[31]
- 2016 Pearl Meister Greengard Prize[32][33]
- 2016 Max Planck Research Award[34]
- 2016 Elected member of the National Academy of Medicine[35]
- 2018 Dickson Prize[36]
- 2018 Ernst Schering Prize[37]
- 2020 Genetics Society of America Medal[38]
- 2020 Gruber Prize in Genetics[39]
- 2021 Paul Ehrlich and Ludwig Darmstaedter Prize[40]
Selected works[]
- Ng, W. L., & Bassler, B. L. (2009). Bacterial quorum-sensing network architectures. Annual review of genetics, 43, 197–222.[41]
- Bassler, B. L., & Losick, R. (2006). Bacterially speaking. Cell, 125(2), 237–246.[42]
- Camilli, A., & Bassler, B. L. (2006). Bacterial small-molecule signaling pathways. Science, 311(5764), 1113–1116.[43]
- Waters, C. M., & Bassler, B. L. (2005). Quorum sensing: cell-to-cell communication in bacteria. Annu. Rev. Cell Dev. Biol., 21, 319–346.[44]
- Lenz, D. H., Mok, K. C., Lilley, B. N., Kulkarni, R. V., Wingreen, N. S., & Bassler, B. L. (2004). The small RNA chaperone Hfq and multiple small RNAs control quorum sensing in Vibrio harveyi and Vibrio cholerae. Cell, 118(1), 69–82.[45]
- Chen, X., Schauder, S., Potier, N., Van Dorsselaer, A., Pelczer, I., Bassler, B. L., & Hughson, F. M. (2002). Structural identification of a bacterial quorum-sensing signal containing boron. Nature, 415(6871), 545.[46]
- Miller, M. B., & Bassler, B. L. (2001). Quorum sensing in bacteria. Annual Reviews in Microbiology, 55(1), 165–199.[47]
- Schauder, S., Shokat, K., Surette, M. G., & Bassler, B. L. (2001). The LuxS family of bacterial autoinducers: biosynthesis of a novel quorum‐sensing signal molecule. Molecular microbiology, 41(2), 463–476.[48]
- Surette, M. G., Miller, M. B., & Bassler, B. L. (1999). Quorum sensing in Escherichia coli, Salmonella typhimurium, and Vibrio harveyi: a new family of genes responsible for autoinducer production. Proceedings of the National Academy of Sciences, 96(4), 1639–1644.[49]
- Bassler, B. L. (1999). How bacteria talk to each other: regulation of gene expression by quorum sensing. Current opinion in microbiology, 2(6), 582–587.[50]
- Bassler, B. L., Wright, M., Showalter, R. E., & Silverman, M. R. (1993). Intercellular signalling in Vibrio harveyi: sequence and function of genes regulating expression of luminescence. Molecular microbiology, 9(4), 773–786.[51]
References[]
- ^ Staff. "Professor Bonnie L. Bassler ForMemRS". The Royal Society. Retrieved October 21, 2012.
- ^ Jump up to: a b "Book of Members, 1780–2010: Chapter B" (PDF). American Academy of Arts and Sciences. Retrieved May 20, 2011.
- ^ "Bonnie Bassler at Princeton". March 11, 2016.
- ^ Jump up to: a b "MacArthur Foundation". www.macfound.org.
- ^ "Princeton university news". Archived from the original on October 17, 2018. Retrieved October 10, 2018.
- ^ "Princeton news".
- ^ Jump up to: a b Ahmed, F. (2008). "Profile of Bonnie L. Bassler". Proceedings of the National Academy of Sciences. 105 (13): 4969–4971. Bibcode:2008PNAS..105.4969A. doi:10.1073/pnas.0705870105. PMC 2278219. PMID 18362352.
- ^ "The Shaw Prize – Top prizes for astronomy, life science and mathematics". www.shawprize.org. Retrieved March 16, 2019.[permanent dead link]
- ^ Jump up to: a b Ahmed, Farooq (March 24, 2008). "Profile of Bonnie L. Bassler". Proceedings of the National Academy of Sciences. 105 (13): 4969–4971. Bibcode:2008PNAS..105.4969A. doi:10.1073/pnas.0705870105. ISSN 0027-8424. PMC 2278219. PMID 18362352.
- ^ "Bonnie L. Bassler, Ph.D." Howard Hughes Medical Institute. Retrieved May 20, 2011.
- ^ Schauder, S.; Bassler, B. L. (2001). "The languages of bacteria". Genes & Development. 15 (12): 1468–80. doi:10.1101/gad.899601. PMID 11410527.
- ^ Ahmed, Farooq (April 1, 2008). "Profile of Bonnie L. Bassler". Proceedings of the National Academy of Sciences. 105 (13): 4969–4971. Bibcode:2008PNAS..105.4969A. doi:10.1073/pnas.0705870105. ISSN 0027-8424. PMC 2278219. PMID 18362352.
- ^ "Bonnie Bassler". Broad Institute. March 20, 2018. Retrieved May 3, 2019.
- ^ Ahmed, Farooq (2008). "Profile of Bonnie L. Bassler". Proceedings of the National Academy of Sciences. 105 (13): 4969–4971. Bibcode:2008PNAS..105.4969A. doi:10.1073/pnas.0705870105. PMC 2278219. PMID 18362352.
- ^ Jump up to: a b "Bassler Lab Research". scholar.princeton.edu. Retrieved May 2, 2020.
- ^ mmacfarl (February 7, 2020). "Bonnie Bassler receives Gruber Genetics Prize". molbio.princeton.edu. Retrieved May 2, 2020.
- ^ "The Explorer's Guide to Biology". explorebiology.org. Retrieved May 2, 2020.
- ^ "Elected Fellows". AAAS – The World's Largest General Scientific Society. October 21, 2016. Retrieved March 10, 2017.
- ^ "Special Recognitions 2008". World Cultural Council. Archived from the original on November 5, 2013. Retrieved August 19, 2013.
- ^ "Eighth Annual Wiley Prize in Biomedical Sciences Awarded to Dr. Bonnie Bassler of Princeton University".
- ^ "Wiley Foundation Past winners".
- ^ "The Nifty Fifty (times 2)". USA Science and Engineering Festival. 2010. Archived from the original on July 23, 2012. Retrieved October 20, 2012.
- ^ "National Science Board". National Science Board. Retrieved March 10, 2017.
- ^ http://www.nasonline.org, National Academy of Sciences -. "Richard Lounsbery Award". www.nasonline.org. Retrieved March 10, 2017.
- ^ L’Oréal Foundation (March 26, 2012). "Bonnie Bassler, 2012 L'Oréal-UNESCO Awards Laureate for North America" – via YouTube.
- ^ "American Society for Microbiology". www.asm.org. Retrieved March 10, 2017.[permanent dead link]
- ^ "Members | American Philosophical Society". www.amphilsoc.org. Retrieved March 10, 2017.
- ^ "2014 EMD Millipore Alice C. Evans Award Laureate". www.asm.org. Archived from the original on October 21, 2018. Retrieved October 20, 2018.
- ^ "Two Princeton professors to receive Phi Beta Kappa teaching awards". Princeton University. Archived from the original on October 17, 2018. Retrieved October 20, 2018.
- ^ "Shaw Laureates in 2015 in Life Science and Medicine: Announcement and Citation". Shaw Prize Foundation. Archived from the original on April 2, 2019. Retrieved June 2, 2015.
- ^ "Recipients and Award Lectures". faseb.org. Retrieved March 10, 2017.
- ^ Alex; MacWade, ra. "Molecular biologist Bonnie Bassler receives Rockefeller's Pearl Meister Greengard Prize | The Rockefeller University Benchmarks". Archived from the original on March 12, 2017. Retrieved March 10, 2017.
- ^ "The Pearl Meister Greengard Prize – The Rockefeller University". greengardprize.rockefeller.edu. Retrieved March 10, 2017.
- ^ "AAAS Fellow Bonnie Bassler wins 2016 Max Planck Research Award". American Association for the Advancement of Science. Retrieved October 20, 2018.
- ^ "National Academy of Medicine Elects 80 New Members – National Academy of Medicine". National Academy of Medicine. October 17, 2016. Retrieved October 20, 2018.
- ^ Webteam, University of Pittsburgh University Marketing Communications. "Bonnie Bassler, PhD". www.dicksonprize.pitt.edu. Retrieved October 20, 2018.
- ^ "Ernst Schering Prize 2018 – Schering Stiftung". scheringstiftung.de. Archived from the original on October 21, 2018. Retrieved October 20, 2018.
- ^ "Congratulations to the recipients of the 2020 GSA Awards!". Genetics Society of America. January 29, 2020. Retrieved February 5, 2020.
- ^ "Bonnie wins Gruber Genetics Prize". scholar.princeton.edu. Retrieved May 2, 2020.
- ^ Mrusek, Marco (January 27, 2021). "Mikrobiologen mit Paul Ehrlich- und Ludwig Darmstaedter-Preis geehrt". AerzteZeitung.de (in German). Retrieved January 27, 2021.
- ^ Ng, Wai-Leung; Bassler, Bonnie L. (December 2009). "Bacterial Quorum-Sensing Network Architectures". Annual Review of Genetics. 43 (1): 197–222. doi:10.1146/annurev-genet-102108-134304. ISSN 0066-4197. PMC 4313539. PMID 19686078.
- ^ Bassler, Bonnie L.; Losick, Richard (April 2006). "Bacterially Speaking". Cell. 125 (2): 237–246. doi:10.1016/j.cell.2006.04.001. ISSN 0092-8674. PMID 16630813. S2CID 17056045.
- ^ Camilli, Andrew; Bassler, Bonnie L. (February 24, 2006). "Bacterial Small-Molecule Signaling Pathways". Science. 311 (5764): 1113–1116. Bibcode:2006Sci...311.1113C. doi:10.1126/science.1121357. ISSN 0036-8075. PMC 2776824. PMID 16497924.
- ^ Waters, Christopher M.; Bassler, Bonnie L. (November 2005). "QUORUM SENSING: Cell-to-Cell Communication in Bacteria". Annual Review of Cell and Developmental Biology. 21 (1): 319–346. doi:10.1146/annurev.cellbio.21.012704.131001. ISSN 1081-0706. PMID 16212498. S2CID 16560276.
- ^ Lenz, Derrick H.; Mok, Kenny C.; Lilley, Brendan N.; Kulkarni, Rahul V.; Wingreen, Ned S.; Bassler, Bonnie L. (July 9, 2004). "The Small RNA Chaperone Hfq and Multiple Small RNAs Control Quorum Sensing in Vibrio harveyi and Vibrio cholerae". Cell. 118 (1): 69–82. doi:10.1016/j.cell.2004.06.009. ISSN 0092-8674. PMID 15242645. S2CID 18997499.
- ^ Chen, Xin; Schauder, Stephan; Potier, Noelle; Van Dorsselaer, Alain; Pelczer, István; Bassler, Bonnie L.; Hughson, Frederick M. (January 2002). "Structural identification of a bacterial quorum-sensing signal containing boron". Nature. 415 (6871): 545–549. doi:10.1038/415545a. ISSN 0028-0836. PMID 11823863. S2CID 4334017.
- ^ Miller, Melissa B.; Bassler, Bonnie L. (October 2001). "Quorum Sensing in Bacteria". Annual Review of Microbiology. 55 (1): 165–199. doi:10.1146/annurev.micro.55.1.165. ISSN 0066-4227. PMID 11544353.
- ^ Schauder, Stephan; Shokat, Kevan; Surette, Michael G.; Bassler, Bonnie L. (December 21, 2001). "The LuxS family of bacterial autoinducers: biosynthesis of a novel quorum-sensing signal molecule". Molecular Microbiology. 41 (2): 463–476. doi:10.1046/j.1365-2958.2001.02532.x. ISSN 0950-382X. PMID 11489131. S2CID 24852124.
- ^ Surette, Michael G.; Miller, Melissa B.; Bassler, Bonnie L. (February 16, 1999). "Quorum sensing in Escherichia coli, Salmonella typhimurium, and Vibrio harveyi: A new family of genes responsible for autoinducer production". Proceedings of the National Academy of Sciences. 96 (4): 1639–1644. Bibcode:1999PNAS...96.1639S. doi:10.1073/pnas.96.4.1639. ISSN 0027-8424. PMC 15544. PMID 9990077.
- ^ Bassler, Bonnie L (December 1999). "How bacteria talk to each other: regulation of gene expression by quorum sensing". Current Opinion in Microbiology. 2 (6): 582–587. doi:10.1016/s1369-5274(99)00025-9. ISSN 1369-5274. PMID 10607620.
- ^ Bassler, Bonnie L.; Wright, Miriam; Showalter, Richard E.; Silverman, Michael R. (August 1993). "Intercellular signalling in Vibrio harveyi: sequence and function of genes regulating expression of luminescence". Molecular Microbiology. 9 (4): 773–786. doi:10.1111/j.1365-2958.1993.tb01737.x. ISSN 0950-382X. PMID 8231809. S2CID 36357210.
External links[]
- Presidents of the American Society for Microbiology
- 1962 births
- Living people
- American women biochemists
- Fellows of the American Academy of Arts and Sciences
- Howard Hughes Medical Investigators
- Johns Hopkins University alumni
- MacArthur Fellows
- Richard-Lounsbery Award laureates
- Members of the United States National Academy of Sciences
- Foreign Members of the Royal Society
- American molecular biologists
- Scientists from Chicago
- Princeton University faculty
- University of California, Davis alumni
- Women molecular biologists
- L'Oréal-UNESCO Awards for Women in Science laureates
- 21st-century American women scientists
- Fellows of the American Association for the Advancement of Science
- Members of the American Philosophical Society
- Members of the National Academy of Medicine
- Fellows of the American Academy of Microbiology
- American women academics