Brian Hanley (microbiologist)

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Brian Hanley
NationalityAmerican
OccupationCEO of Butterfly Sciences

Brian Hanley (born c. 1957) is an American microbiologist and founder of Butterfly Sciences. He is known for with gene therapy to try to improve health span.[1][2]

Biography[]

Hanley obtained a PhD in Microbiology from University of California, Davis in 2009.[3][failed verification][4][5] The same year, he founded Butterfly Sciences in Davis, California to develop a gene therapy to treat HIV AIDS using a combination of GHRH[6] and an intracellular vaccine.[5][7] He has published in Rejuvenation Research,[8][9] Virology Journal,[10] Hypotheses in the Life Sciences[11] (now a section in the MDPI journal Life),[12] the predatory publisher iMedPub journal Archivos de Medicina,[13] Theoretical Biology and Medical Modelling,[14] and the Journal of Negative Results in BioMedicine.[15]

Self-experimentation[]

Hanley said that when he could not raise money for Butterfly, he decided to obtain proof of concept by testing the gene therapy on himself. He said that he designed the plasmid containing a gene coding for growth hormone–releasing hormone and had it made by a scientific supply company for around $10,000.[2] However, the total cost of development was over $500,000.[16]

He said that he corresponded with the FDA prior to starting his self-experimentation, and that the FDA told him he needed to file and get approval for an Investigational New Drug (IND) application before he tested the plasmid on a person; not having obtained an IND, he proceeded without it.[2]

He submitted his protocol to a private institutional review board (IRB), the Institute of Regenerative and Cellular Medicine in Santa Monica, California, which advised on his proposed clinical research plans.[2]

A physician assisted in administration of the plasmid to Hanley's thigh using electroporation.[2] The plasmids were administered twice: once in summer 2015 and a second larger dose in July 2016.[2][17][18]

Hanley claims the treatment has helped him.[17][19]

See also[]

References[]

  1. ^ "GHRH plasmid gene therapy for aging". Retrieved 13 November 2017.
  2. ^ a b c d e f Regalado, Antonio. "One man's quest to hack his own genes". MIT Technology Review. Retrieved 23 April 2017.
  3. ^ "Brian Hanley". Institute for Ethics and Emerging Technologies. Retrieved 23 April 2017.
  4. ^ "Brian Hanley - Info". ResearchGate. Retrieved 23 April 2017.
  5. ^ a b "Company | Butterfly Sciences". bf-sci.com. Retrieved 23 April 2017.
  6. ^ "Company: GHRH plasmid gene therapy for aging - lower part of page". Retrieved 13 November 2017.
  7. ^ "Company: Synthetic intra-cellular HIV vaccine". Retrieved 13 November 2017.
  8. ^ Hanley, Brian P; Keen, Steve; Church, George (14 August 2020). "A Call for a Three-Tiered Pandemic Public Health Strategy in Context of SARS-CoV-2". Rejuvenation Research. Mary Ann Liebert, Inc., publishers. 23 (4): 281–283. doi:10.1089/rej.2020.2363. PMC 7462018. PMID 32539623.
  9. ^ Hanley, Brian P; Bains, William; Church, George (19 February 2019). "Review of Scientific Self-Experimentation: Ethics History, Regulation, Scenarios, and Views Among Ethics Committees and Prominent Scientists". Rejuvenation Research. Mary Ann Liebert, Inc., publishers. 22 (1): 31–42. doi:10.1089/rej.2018.2059. PMID 29926769.
  10. ^ Hanley, Brian P; Borup, Birthe (14 May 2010). "Aerosol influenza transmission risk contours: A study of humid tropics versus winter temperate zone". Virology Journal. BMC. 7 (98): 98. doi:10.1186/1743-422X-7-98. PMC 2893155. PMID 20470403.
  11. ^ Hanley, Brian P (2011). "DUAL-GENDER MACRO-CHIMERIC TISSUE DISCORDANCE IS PREDICTED TO BE A SIGNIFICANT CAUSE OF HUMAN HOMOSEXUALITY AND TRANSGENDERISM". Hypotheses in the Life Sciences. 1 (3): 63–70. ISSN 2042-8960. Retrieved 7 June 2021.
  12. ^ Bains, William (August 2014). "HYPOTHESES IN THE LIFE SCIENCES MOVES TO NEW PUBLISHER". Hypotheses in the Life Sciences. Retrieved 7 June 2021.
  13. ^ Hanley, Brian P; Borup, Birthe (2010). "Perfiles de riesgo de transmisión de la gripe por aerosol: Un estudio de los trópicos húmedos frente a la zona templada". Archivos de Medicina. iMedPub Journals. 6 (2:4). doi:10.3823/061. Retrieved 7 June 2021.
  14. ^ Hanley, Brian P; Xing, Li; Cheng, R Holland (23 August 2007). "Variance in multiplex suspension array assays: microsphere size variation impact". Theoretical Biology and Medical Modelling. 4 (31): 31. doi:10.1186/1742-4682-4-31. PMC 2041949. PMID 17716372.
  15. ^ Hanley, Brian (25 April 2007). "ariance in multiplex suspension array assays: carryover of microspheres between sample wells". Journal of Negative Results in BioMedicine. BMC. 6 (6): 6. doi:10.1186/1477-5751-6-6. PMC 1865554. PMID 17459164.
  16. ^ Paul Tullis. "Are You Rich Enough To Live Forever?". Town & Country. Retrieved 12 February 2017.
  17. ^ a b Friend, Tad (3 April 2017). "Silicon Valley's Quest to Live Forever". The New Yorker. Retrieved 23 April 2017.
  18. ^ Giuliano Aluffi (12 February 2017). "Scienziato transgenico per l'elisir di lunga vita: "Così ho modificato le mie cellule"". Repubblica.it (in Italian). Retrieved 23 April 2017.
  19. ^ Brian Hanley (30 May 2017). "Status of the GHRH gene therapy project". Butterfly Sciences. Retrieved 20 Nov 2017.[permanent dead link]

External links[]

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