Bufalin
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Names | |
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IUPAC name
3β,14-Dihydroxy-5β-bufa-20,22-dienolide
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Preferred IUPAC name
4-[(1R,3aS,3bR,5aR,7S,9aS,9bS,11aR)-3a,7-Dihydroxy-9a,11a-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]-2H-pyran-2-one | |
Identifiers | |
3D model (JSmol)
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ChEBI | |
ChEMBL | |
ChemSpider | |
ECHA InfoCard | 100.150.073 ![]() |
PubChem CID
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UNII | |
CompTox Dashboard (EPA)
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Properties | |
C24H34O4 | |
Molar mass | 386.532 g·mol−1 |
Hazards | |
GHS labelling: | |
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Signal word
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Danger |
H300 | |
P264, P270, P301+P310, P321, P330, P405, P501 | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
Infobox references | |
Bufalin, is a cardiotonic steroid originally isolated from the Chinese toad venom. It is a component found in many Chinese traditional medicine.[1][2]
Usage[]
Bufalin has an in vitro antitumor effects against various malignancies, including hepatocellular[3] and lung carcinoma.[4] However, as with other bufadienolides, its use is hampered by its cardiotoxicity.[5]
References[]
- ^ "Datasheet: Bufotalin sc-sc-200136" Santa Cruz Biotechnology, Inc.https://datasheets.scbt.com/sc-200136.pdf
- ^ Okada, Masahiro; Suga, Toshiro; et al. (April 1960). "Pharmacology of the priniciples isolated from Senso (Ch'an Su) the dried venom of the Chinese toad (IV)" (PDF). . 3 (4): 155–160.
- ^ Zhang ZJ (Feb 2014). "Bufalin attenuates the stage and metastatic potential of hepatocellular carcinoma in nude mice". J Transl Med. 12: 57. doi:10.1186/1479-5876-12-57. PMC 4015709. PMID 24581171.
- ^ Wu SH (2014). "Bufalin induces cell death in human lung cancer cells through disruption of DNA damage response pathways". Am J Chin Med. 42 (3): 729–42. doi:10.1142/S0192415X14500475. PMID 24871662.
- ^ Ma H (Jul 2012). "The novel antidote Bezoar Bovis prevents the cardiotoxicity of Toad (Bufo bufo gargarizans Canto) Venom in mice". Exp Toxicol Pathol. 64 (5): 417–23. doi:10.1016/j.etp.2010.10.007. PMID 21084181.
Categories:
- Bufanolides
- Cardiac stimulants