Bxd (gene)

Bithoraxoid conserved region 1
Bithoraxoid conserved region 1
	Conserved secondary structure of Bithoraxoid conserved region 1
Identifiers
Symbol	bxd_1
Rfam	RF01929
Other data
RNA type	Gene
Domain(s)	Drosophila
PDB structures	PDBe

Bithoraxoid (bxd) is a long non-coding RNA found in Drosophila. It silences the expression of the Ultrabithorax (Ubx) gene by transcriptional interference.^[1]^[2]

References[]

^ Petruk S, Sedkov Y, Riley KM, et al. (December 2006). "Transcription of bxd noncoding RNAs promoted by trithorax represses Ubx in cis by transcriptional interference". Cell. 127 (6): 1209–1221. doi:10.1016/j.cell.2006.10.039. PMC 1866366. PMID 17174895.
^ Petruk S, Sedkov Y, Brock HW, Mazo A (2007). "A model for initiation of mosaic HOX gene expression patterns by non-coding RNAs in early embryos". RNA Biol. 4 (1): 1–6. doi:10.4161/rna.4.1.4300. PMID 17568198.

Further reading[]

Janssen R, Budd GE (2010). "Gene expression suggests conserved aspects of Hox gene regulation in arthropods and provides additional support for monophyletic Myriapoda". Evodevo. 1 (1): 4. doi:10.1186/2041-9139-1-4. PMC 2938723. PMID 20849647.
Kozma G, Bender W, Sipos L (June 2008). "Replacement of a Drosophila Polycomb response element core, and in situ analysis of its DNA motifs". Mol. Genet. Genomics. 279 (6): 595–603. doi:10.1007/s00438-008-0336-3. PMID 18350319.
Faucheux M, Roignant JY, Netter S, Charollais J, Antoniewski C, Théodore L (February 2003). "batman Interacts with polycomb and trithorax group genes and encodes a BTB/POZ protein that is included in a complex containing GAGA factor". Mol. Cell. Biol. 23 (4): 1181–1195. doi:10.1128/mcb.23.4.1181-1195.2003. PMC 141128. PMID 12556479.
Huang DH, Chang YL, Yang CC, Pan IC, King B (September 2002). "pipsqueak encodes a factor essential for sequence-specific targeting of a polycomb group protein complex". Mol. Cell. Biol. 22 (17): 6261–6271. doi:10.1128/mcb.22.17.6261-6271.2002. PMC 134006. PMID 12167718.
Rivlin PK, Gong A, Schneiderman AM, Booker R (February 2001). "The role of Ultrabithorax in the patterning of adult thoracic muscles in Drosophila melanogaster". Dev. Genes Evol. 211 (2): 55–66. doi:10.1007/s004270000126. PMID 11455415.
Hodgson JW, Argiropoulos B, Brock HW (July 2001). "Site-specific recognition of a 70-base-pair element containing d(GA)(n) repeats mediates bithoraxoid polycomb group response element-dependent silencing". Mol. Cell. Biol. 21 (14): 4528–4543. doi:10.1128/MCB.21.14.4528-4543.2001. PMC 87112. PMID 11416132.

External links[]

[pmid17174895-1] Petruk S, Sedkov Y, Riley KM, et al. (December 2006). "Transcription of bxd noncoding RNAs promoted by trithorax represses Ubx in cis by transcriptional interference". Cell. 127 (6): 1209–1221. doi:10.1016/j.cell.2006.10.039. PMC 1866366. PMID 17174895.

[pmid17568198-2] Petruk S, Sedkov Y, Brock HW, Mazo A (2007). "A model for initiation of mosaic HOX gene expression patterns by non-coding RNAs in early embryos". RNA Biol. 4 (1): 1–6. doi:10.4161/rna.4.1.4300. PMID 17568198.

[1]

[2]