CALML5

CALML5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2B1U
Identifiers
Aliases	CALML5, CLSP, calmodulin like 5
External IDs	OMIM: 605183 MGI: 1931464 HomoloGene: 49485 GeneCards: CALML5
Gene location (Human)
Chr.	Chromosome 10 (human)
End	5,499,570 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	3,888,673 bp
RNA expression pattern
	Top expressed in
	vulva; ; salivary gland; ; zone of skin; ; human penis; ; minor salivary gland; ; nipple;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; calcium ion binding; GO:0010576 enzyme regulator activity;
Cellular component	extracellular region; ficolin-1-rich granule lumen; nucleus;
Biological process	signal transduction; epidermis development; neutrophil degranulation; calcium-mediated signaling; GO:0048552 regulation of catalytic activity; spindle pole body organization;
	Sources:Amigo / QuickGO
Orthologs
	51806
	80796
	ENSG00000178372
	ENSMUSG00000033765
	Q9NZT1
	Q9JM83
	NM_017422
	NM_020036
	NP_059118
	NP_064420
	Wikidata
View/Edit Human	View/Edit Mouse

Calmodulin-like protein 5 is a protein that in humans is encoded by the CALML5 gene.^[5]^[6]

This gene encodes a novel calcium binding protein expressed in the epidermis and related to the calmodulin family of calcium binding proteins. Functional studies with recombinant protein demonstrate it does bind calcium and undergoes a conformational change when it does so. Abundant expression is detected only in reconstructed epidermis and is restricted to differentiating keratinocytes. In addition, it can associate with transglutaminase 3, shown to be a key enzyme in the terminal differentiation of keratinocytes.^[6]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000178372 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033765 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mehul B, Bernard D, Simonetti L, Bernard MA, Schmidt R (Jun 2000). "Identification and cloning of a new calmodulin-like protein from human epidermis". J Biol Chem. 275 (17): 12841–7. doi:10.1074/jbc.275.17.12841. PMID 10777582.
^ ^a ^b "Entrez Gene: CALML5 calmodulin-like 5".

External links[]

Human CALML5 genome location and CALML5 gene details page in the UCSC Genome Browser.
Overview of all the structural information available in the PDB for UniProt: Q9NZT1 (Human Calmodulin-like protein 5) at the PDBe-KB.

Further reading[]

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Méhul B, Bernard D, Schmidt R (2001). "Calmodulin-like skin protein: a new marker of keratinocyte differentiation". J. Invest. Dermatol. 116 (6): 905–9. doi:10.1046/j.0022-202x.2001.01376.x. PMID 11407979.
Durussel I, Méhul B, Bernard D, et al. (2002). "Cation- and peptide-binding properties of human calmodulin-like skin protein". Biochemistry. 41 (17): 5439–48. doi:10.1021/bi016062z. PMID 11969404.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Méhul B, Bernard D, Brouard M, et al. (2006). "Influence of calcium on the proteolytic degradation of the calmodulin-like skin protein (calmodulin-like protein 5) in psoriatic epidermis". Exp. Dermatol. 15 (6): 469–77. doi:10.1111/j.1600-0625.2006.00433.x. PMID 16689864. S2CID 32717375.
Babini E, Bertini I, Capozzi F, et al. (2006). "A structural and dynamic characterization of the EF-hand protein CLSP". Structure. 14 (6): 1029–38. doi:10.1016/j.str.2006.04.004. PMID 16765896.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by .

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000178372 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000033765 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10777582-5] Mehul B, Bernard D, Simonetti L, Bernard MA, Schmidt R (Jun 2000). "Identification and cloning of a new calmodulin-like protein from human epidermis". J Biol Chem. 275 (17): 12841–7. doi:10.1074/jbc.275.17.12841. PMID 10777582.

[entrez-6] "Entrez Gene: CALML5 calmodulin-like 5".

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