Chromobox homolog 7 is a protein that in humans is encoded by the CBX7 gene .[5] CBX7 gene expression has been shown to correlate with a malignant form of thyroid cancer .[6]
Model organisms [ ] Model organisms have been used in the study of CBX7 function. A conditional knockout mouse line, called Cbx7tm1a(KOMP)Wtsi [13] [14] International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute .[15] [16] [17] phenotypic screen to determine the effects of deletion.[11] [18] phenotypes were reported. Homozygous mutant female adults showed a decreased response to stress-induced hyperthermia and had an increased red blood cell count. Animals of both sex had an integument phenotype when tail epidermis was examined.[11]
References [ ]
^ a b c GRCh38: Ensembl release 89: ENSG00000100307 - Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000053411 - Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Chromobox homolog 7" . Retrieved 2011-12-06 .^ Pallante P, Federico A, Berlingieri MT, Bianco M, Ferraro A, Forzati F, et al. (August 2008). "Loss of the CBX7 gene expression correlates with a highly malignant phenotype in thyroid cancer" . Cancer Research . 68 (16): 6770–8. doi :10.1158/0008-5472.CAN-08-0695 PMID 18701502 . ^ "Body temperature data for Cbx7" . Wellcome Trust Sanger Institute.^ "Haematology data for Cbx7" . Wellcome Trust Sanger Institute.^ "Salmonella infection data for Cbx7" . Wellcome Trust Sanger Institute.^ "Citrobacter infection data for Cbx7" . Wellcome Trust Sanger Institute.^ a b c Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica . 88 (S248). doi :10.1111/j.1755-3768.2010.4142.x . S2CID 85911512 . ^ Mouse Resources Portal , Wellcome Trust Sanger Institute.^ "International Knockout Mouse Consortium" . Archived from the original on 2012-03-20. Retrieved 2012-01-05 .^ "Mouse Genome Informatics" .^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, et al. (June 2011). "A conditional knockout resource for the genome-wide study of mouse gene function" . Nature . 474 (7351): 337–42. doi :10.1038/nature10163 . PMC 3572410 PMID 21677750 . ^ Dolgin E (June 2011). "Mouse library set to be knockout" . Nature . 474 (7351): 262–3. doi :10.1038/474262a PMID 21677718 . ^ Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons" . Cell . 128 (1): 9–13. doi :10.1016/j.cell.2006.12.018 PMID 17218247 . S2CID 18872015 . ^ van der Weyden L, White JK, Adams DJ, Logan DW (June 2011). "The mouse genetics toolkit: revealing function and mechanism" . Genome Biology . 12 (6): 224. doi :10.1186/gb-2011-12-6-224 . PMC 3218837 PMID 21722353 .
Further reading [ ]
Yap KL, Li S, Muñoz-Cabello AM, Raguz S, Zeng L, Mujtaba S, et al. (June 2010). "Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a" . Molecular Cell . 38 (5): 662–74. doi :10.1016/j.molcel.2010.03.021 . PMC 2886305 PMID 20541999 . Federico A, Pallante P, Bianco M, Ferraro A, Esposito F, Monti M, et al. (September 2009). "Chromobox protein homologue 7 protein, with decreased expression in human carcinomas, positively regulates E-cadherin expression by interacting with the histone deacetylase 2 protein" . Cancer Research . 69 (17): 7079–87. doi :10.1158/0008-5472.CAN-09-1542 PMID 19706751 . Pallante P, Terracciano L, Carafa V, Schneider S, Zlobec I, Lugli A, et al. (August 2010). "The loss of the CBX7 gene expression represents an adverse prognostic marker for survival of colon carcinoma patients". European Journal of Cancer . 46 (12): 2304–13. doi :10.1016/j.ejca.2010.05.011 . PMID 20542683 . Zhang XW, Zhang L, Qin W, Yao XH, Zheng LZ, Liu X, et al. (August 2010). "Oncogenic role of the chromobox protein CBX7 in gastric cancer" . Journal of Experimental & Clinical Cancer Research . 29 (1): 114. doi :10.1186/1756-9966-29-114 . PMC 2933612 PMID 20723236 . Hu CK, Wang W, Brind'Amour J, Singh PP, Reeves GA, Lorincz MC, Alvarado AS, Brunet A (February 2020). "Vertebrate diapause preserves organisms long term through Polycomb complex members" . Science . 367 (6480): 870–874. doi :10.1126/science.aaw2601 . PMC 7532943 PMID 32079766 .
