CCNB1IP1

CCNB1IP1
Identifiers
Aliases	CCNB1IP1, C14orf18, HEI10, cyclin B1 interacting protein 1
External IDs	OMIM: 608249 MGI: 2685134 HomoloGene: 18819 GeneCards: CCNB1IP1
Gene location (Human)
Chr.	Chromosome 14 (human)
End	20,333,312 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	51,045,189 bp
RNA expression pattern
	Top expressed in
	kidney; ; ovary; ; heart; ; esophagus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	GO:0001948 protein binding; metal ion binding; GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity; transferase activity;
Cellular component	condensed nuclear chromosome; synaptonemal complex; nucleus; chromosome;
Biological process	reciprocal meiotic recombination; chiasma assembly; GO:0007126 meiosis; blastocyst formation; protein ubiquitination; spermatid development;
	Sources:Amigo / QuickGO
Orthologs
	57820
	239083
	ENSG00000100814
	ENSMUSG00000071470
	Q9NPC3
	D3Z3K2
	NM_182852; NM_021178; NM_182849; NM_182851
	NM_001111119
	NP_067001; NP_878269; NP_878272
	NP_001104589
	Wikidata
View/Edit Human	View/Edit Mouse

E3 ubiquitin-protein ligase CCNB1IP1 is an enzyme that in humans is encoded by the CCNB1IP1 gene.^[5]^[6]

HEI10 is a member of the E3 ubiquitin ligase family and functions in progression of the cell cycle through G(2)/M.[supplied by OMIM]^[6] It is considered a housekeeping gene.

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100814 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000071470 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Toby GG, Gherraby W, Coleman TR, Golemis EA (Mar 2003). "A Novel RING Finger Protein, Human Enhancer of Invasion 10, Alters Mitotic Progression through Regulation of Cyclin B Levels". Mol Cell Biol. 23 (6): 2109–2122. doi:10.1128/MCB.23.6.2109-2122.2003. PMC 149478. PMID 12612082.
^ ^a ^b "Entrez Gene: CCNB1IP1 cyclin B1 interacting protein 1".

External links[]

Human CCNB1IP1 genome location and CCNB1IP1 gene details page in the UCSC Genome Browser.

Further reading[]

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–828. doi:10.1101/gr.6.9.807. PMID 8889549.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–1795. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–435. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–2144. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Grönholm M, Muranen T, Toby GG, et al. (2006). "A functional association between merlin and HEI10, a cell cycle regulator". Oncogene. 25 (32): 4389–4398. doi:10.1038/sj.onc.1209475. PMID 16532029.

This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by .

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100814 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000071470 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12612082-5] Toby GG, Gherraby W, Coleman TR, Golemis EA (Mar 2003). "A Novel RING Finger Protein, Human Enhancer of Invasion 10, Alters Mitotic Progression through Regulation of Cyclin B Levels". Mol Cell Biol. 23 (6): 2109–2122. doi:10.1128/MCB.23.6.2109-2122.2003. PMC 149478. PMID 12612082.

[entrez-6] "Entrez Gene: CCNB1IP1 cyclin B1 interacting protein 1".

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