CCNL1

CCNL1
Identifiers
Aliases	CCNL1, ANIA6A, PRO1073, ania-6a, BM-001, cyclin L1
External IDs	OMIM: 613384 MGI: 1922664 HomoloGene: 10541 GeneCards: CCNL1
Gene location (Human)
Chr.	Chromosome 3 (human)
End	157,160,760 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	65,865,670 bp
RNA expression pattern
	Top expressed in
	bone marrow; ; anterior pituitary; ; gastric mucosa;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cyclin-dependent protein serine/threonine kinase regulator activity; GO:0001948 protein binding;
Cellular component	nuclear speck; cyclin-dependent protein kinase holoenzyme complex; nucleoplasm; nucleus;
Biological process	positive regulation of phosphorylation of RNA polymerase II C-terminal domain; RNA processing; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of transcription, DNA-templated; transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; positive regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	57018
	56706
	ENSG00000163660
	ENSMUSG00000027829
	Q9UK58
	Q52KE7
	NM_001308185; NM_020307
	NM_001025442; NM_001025443; NM_019937; NM_001355432; NM_001355433
	NP_001295114; NP_064703
	NP_064321; NP_001342361; NP_001342362
	Wikidata
View/Edit Human	View/Edit Mouse

Cyclin-L1 is a protein that in humans is encoded by the CCNL1 gene.^[5]^[6]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163660 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027829 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dickinson LA, Edgar AJ, Ehley J, Gottesfeld JM (Jul 2002). "Cyclin L is an RS domain protein involved in pre-mRNA splicing". J Biol Chem. 277 (28): 25465–73. doi:10.1074/jbc.M202266200. PMID 11980906.
^ "Entrez Gene: CCNL1 cyclin L1".

External links[]

Human CCNL1 genome location and CCNL1 gene details page in the UCSC Genome Browser.

Further reading[]

Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
Berke JD, Sgambato V, Zhu PP, et al. (2001). "Dopamine and glutamate induce distinct striatal splice forms of Ania-6, an RNA polymerase II-associated cyclin". Neuron. 32 (2): 277–87. doi:10.1016/S0896-6273(01)00465-2. PMID 11683997. S2CID 14486999.
Redon R, Hussenet T, Bour G, et al. (2002). "Amplicon mapping and transcriptional analysis pinpoint cyclin L as a candidate oncogene in head and neck cancer". Cancer Res. 62 (21): 6211–7. PMID 12414649.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
de Graaf K, Hekerman P, Spelten O, et al. (2004). "Characterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain: phosphorylation by DYRK1A and colocalization with splicing factors". J. Biol. Chem. 279 (6): 4612–24. doi:10.1074/jbc.M310794200. PMID 14623875.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Sticht C, Hofele C, Flechtenmacher C, et al. (2005). "Amplification of Cyclin L1 is associated with lymph node metastases in head and neck squamous cell carcinoma (HNSCC)". Br. J. Cancer. 92 (4): 770–4. doi:10.1038/sj.bjc.6602400. PMC 2361871. PMID 15700036.
Muller D, Millon R, Théobald S, et al. (2006). "Cyclin L1 (CCNL1) gene alterations in human head and neck squamous cell carcinoma". Br. J. Cancer. 94 (7): 1041–4. doi:10.1038/sj.bjc.6603036. PMC 2361229. PMID 16598186.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by .

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163660 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027829 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11980906-5] Dickinson LA, Edgar AJ, Ehley J, Gottesfeld JM (Jul 2002). "Cyclin L is an RS domain protein involved in pre-mRNA splicing". J Biol Chem. 277 (28): 25465–73. doi:10.1074/jbc.M202266200. PMID 11980906.

[entrez-6] "Entrez Gene: CCNL1 cyclin L1".

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