CITED1

CITED1
Identifiers
Aliases	CITED1, MSG1, Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1
External IDs	OMIM: 300149 MGI: 108023 HomoloGene: 3057 GeneCards: CITED1
Gene location (Human)
Chr.	X chromosome (human)
End	72,307,187 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	101,295,787 bp
RNA expression pattern
	Top expressed in
	anterior pituitary; ; pituitary gland; ; corpus epididymis; ; testicle; ; caput epididymis; ; hypothalamus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	GO:0001105 transcription coactivator activity; co-SMAD binding; protein homodimerization activity; GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; chromatin binding; LBD domain binding; protein C-terminus binding; GO:0001948 protein binding;
Cellular component	cytoplasm; cytosol; nucleus; nucleoplasm;
Biological process	negative regulation of neuron apoptotic process; response to transforming growth factor beta; positive regulation of transforming growth factor beta receptor signaling pathway; cell differentiation; response to cytokine; melanin biosynthetic process; spongiotrophoblast layer development; response to interleukin-1; regulation of transcription, DNA-templated; SMAD protein signal transduction; response to interleukin-4; response to interferon-gamma; response to interleukin-6; placenta development; regulation of transcription by RNA polymerase II; response to interleukin-2; negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis; labyrinthine layer development; response to interleukin-11; negative regulation of Wnt signaling pathway; embryonic axis specification; negative regulation of osteoblast differentiation; transcription, DNA-templated; response to estrogen; vasculogenesis; positive regulation of transcription, DNA-templated; response to insulin; multicellular organism development; response to lipopolysaccharide; branching involved in ureteric bud morphogenesis; brain development; positive regulation of gene expression; response to parathyroid hormone; nucleocytoplasmic transport; pigmentation; response to cAMP; cell population proliferation; metanephros development; melanocyte differentiation; negative regulation of transcription, DNA-templated; response to interleukin-9; transforming growth factor beta receptor signaling pathway; mesenchymal to epithelial transition; apoptotic process; positive regulation of transcription by RNA polymerase II; regulation of apoptotic process; transcription by RNA polymerase II; positive regulation of mesenchymal stem cell proliferation;
	Sources:Amigo / QuickGO
Orthologs
	4435
	12705
	ENSG00000125931
	ENSMUSG00000051159
	Q99966
	P97769
	NM_001144885; NM_001144886; NM_001144887; NM_004143
	NM_001276466; NM_001276473; NM_001276474; NM_007709
	NP_001138357; NP_001138358; NP_001138359; NP_004134
	NP_001263395; NP_001263402; NP_001263403; NP_031735
	Wikidata
View/Edit Human	View/Edit Mouse

Cbp/p300-interacting transactivator 1 is a protein that in humans is encoded by the CITED1 gene.^[5]^[6]^[7]

Interactions[]

CITED1 has been shown to interact with HSPA8^[8] and EP300.^[8]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000125931 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000051159 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Shioda T, Fenner MH, Isselbacher KJ (December 1996). "msg1, a novel melanocyte-specific gene, encodes a nuclear protein and is associated with pigmentation". Proc Natl Acad Sci U S A. 93 (22): 12298–303. Bibcode:1996PNAS...9312298S. doi:10.1073/pnas.93.22.12298. PMC 37985. PMID 8901575.
^ Fenner MH, Parrish JE, Boyd Y, Reed V, MacDonald M, Nelson DL, Isselbacher KJ, Shioda T (October 1998). "MSG1 (melanocyte-specific gene 1): mapping to chromosome Xq13.1, genomic organization, and promoter analysis". Genomics. 51 (3): 401–7. doi:10.1006/geno.1998.5383. PMID 9721210.
^ "Entrez Gene: CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1".
^ ^a ^b Yahata, T; de Caestecker M P; Lechleider R J; Andriole S; Roberts A B; Isselbacher K J; Shioda T (March 2000). "The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors". J. Biol. Chem. UNITED STATES. 275 (12): 8825–34. doi:10.1074/jbc.275.12.8825. ISSN 0021-9258. PMID 10722728.

External links[]

Human CITED1 genome location and CITED1 gene details page in the UCSC Genome Browser.

Further reading[]

Shioda T, Fenner MH, Isselbacher KJ (1998). "MSG1 and its related protein MRG1 share a transcription activating domain". Gene. 204 (1–2): 235–41. doi:10.1016/S0378-1119(97)00551-9. PMID 9434189.
Li H, Ahmed NU, Fenner MH, et al. (1998). "Regulation of expression of MSG1 melanocyte-specific nuclear protein in human melanocytes and melanoma cells". Exp. Cell Res. 242 (2): 478–86. doi:10.1006/excr.1998.4123. PMID 9683535.
Shioda T, Lechleider RJ, Dunwoodie SL, et al. (1998). "Transcriptional activating activity of Smad4: roles of SMAD hetero-oligomerization and enhancement by an associating transactivator". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 9785–90. Bibcode:1998PNAS...95.9785S. doi:10.1073/pnas.95.17.9785. PMC 21414. PMID 9707553.
Vachtenheim J, Novotná H (2000). "Expression of genes for microphthalmia isoforms, Pax3 and MSG1, in human melanomas". Cell. Mol. Biol. (Noisy-le-grand). 45 (7): 1075–82. PMID 10644012.
Yahata T, de Caestecker MP, Lechleider RJ, et al. (2000). "The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors". J. Biol. Chem. 275 (12): 8825–34. doi:10.1074/jbc.275.12.8825. PMID 10722728.
Ahmed NU, Shioda T, Coser KR, et al. (2001). "Aberrant expression of MSG1 transcriptional activator in human malignant melanoma in vivo". Pigment Cell Res. 14 (2): 140–3. PMID 11310794.
Iwasaki T, Chin WW, Ko L (2001). "Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM)". J. Biol. Chem. 276 (36): 33375–83. doi:10.1074/jbc.M101517200. PMID 11443112.
Yahata T, Shao W, Endoh H, et al. (2001). "Selective coactivation of estrogen-dependent transcription by CITED1 CBP/p300-binding protein". Genes Dev. 15 (19): 2598–612. doi:10.1101/gad.906301. PMC 312794. PMID 11581164.
Bragança J, Swingler T, Marques FI, et al. (2002). "Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2". J. Biol. Chem. 277 (10): 8559–65. doi:10.1074/jbc.M110850200. PMID 11744733.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Shi G, Boyle SC, Sparrow DB, et al. (2006). "The transcriptional activity of CITED1 is regulated by phosphorylation in a cell cycle-dependent manner". J. Biol. Chem. 281 (37): 27426–35. doi:10.1074/jbc.M602631200. PMID 16864582.
Lovvorn HN, Westrup J, Opperman S, et al. (2007). "CITED1 expression in Wilms' tumor and embryonic kidney". Neoplasia. 9 (7): 589–600. doi:10.1593/neo.07358. PMC 1941694. PMID 17710162.

This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by .

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000125931 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000051159 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8901575-5] Shioda T, Fenner MH, Isselbacher KJ (December 1996). "msg1, a novel melanocyte-specific gene, encodes a nuclear protein and is associated with pigmentation". Proc Natl Acad Sci U S A. 93 (22): 12298–303. Bibcode:1996PNAS...9312298S. doi:10.1073/pnas.93.22.12298. PMC 37985. PMID 8901575.

[pmid9721210-6] Fenner MH, Parrish JE, Boyd Y, Reed V, MacDonald M, Nelson DL, Isselbacher KJ, Shioda T (October 1998). "MSG1 (melanocyte-specific gene 1): mapping to chromosome Xq13.1, genomic organization, and promoter analysis". Genomics. 51 (3): 401–7. doi:10.1006/geno.1998.5383. PMID 9721210.

[entrez-7] "Entrez Gene: CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1".

[pmid10722728-8] Yahata, T; de Caestecker M P; Lechleider R J; Andriole S; Roberts A B; Isselbacher K J; Shioda T (March 2000). "The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors". J. Biol. Chem. UNITED STATES. 275 (12): 8825–34. doi:10.1074/jbc.275.12.8825. ISSN 0021-9258. PMID 10722728.

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