CLTC

CLTC
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2XZG, 4G55
Identifiers
Aliases	CLTC, CHC, CHC17, CLH-17, CLTCL2, Hc, clathrin heavy chain, MRD56
External IDs	OMIM: 118955 MGI: 2388633 HomoloGene: 3572 GeneCards: CLTC
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q23.1 Start 59,619,689 bp[1] End 59,696,956 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 C Start 86,694,351 bp[2] End 86,757,565 bp[2]
RNA expression pattern Bgee Top expressed in dorsolateral prefrontal cortex caudate nucleus Brodmann area 46 middle temporal gyrus postcentral gyrus pituitary gland visceral pleura superior frontal gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function GO:0001948 protein binding double-stranded RNA binding protein kinase binding structural molecule activity RNA binding clathrin light chain binding disordered domain specific binding low-density lipoprotein particle receptor binding ubiquitin-specific protease binding Cellular component extracellular vesicle cytosol clathrin-coated endocytic vesicle membrane clathrin coat of coated pit trans-Golgi network membrane clathrin coat of trans-Golgi network vesicle focal adhesion melanosome plasma membrane endolysosome membrane clathrin-coated pit extracellular exosome cytoplasmic vesicle membrane GO:0016023 cytoplasmic vesicle clathrin-coated vesicle GO:0005578 extracellular matrix membrane mitotic spindle microtubule cytoplasm lysosome endosome spindle cytoskeleton clathrin coat clathrin complex protein-containing complex intracellular membrane-bounded organelle clathrin-coated endocytic vesicle mitotic spindle intracellular anatomical structure Biological process antigen processing and presentation of exogenous peptide antigen via MHC class II transferrin transport receptor internalization negative regulation of protein localization to plasma membrane retrograde transport, endosome to Golgi osteoblast differentiation vesicle-mediated transport negative regulation of hyaluronan biosynthetic process intracellular protein transport Wnt signaling pathway, planar cell polarity pathway regulation of mitotic spindle organization autophagy microtubule-based movement cell cycle cell division membrane organization GO:0007067 mitotic cell cycle receptor-mediated endocytosis low-density lipoprotein particle receptor catabolic process low-density lipoprotein particle clearance clathrin coat assembly clathrin-dependent endocytosis amyloid-beta clearance by transcytosis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1213	67300
Ensembl	ENSG00000141367	ENSMUSG00000047126
UniProt	Q00610	Q68FD5
RefSeq (mRNA)	NM_001288653 NM_004859	NM_001003908 NM_001356393
RefSeq (protein)	NP_001275582 NP_004850	NP_001003908 NP_001343322
Location (UCSC)	Chr 17: 59.62 – 59.7 Mb	Chr 11: 86.69 – 86.76 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Clathrin heavy chain 1 is a protein that in humans is encoded by the CLTC gene.^[5][6]

Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains.^[7] }}

Interactions[]

CLTC has been shown to interact with PICALM^[8] and HGS.^[9]

See also[]

• Clathrin

References[]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Further reading[]

External links[]

• Human CLTC genome location and CLTC gene details page in the UCSC Genome Browser.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by .

• v
• t