Coronin, actin binding protein, 2A is a protein that in humans is encoded by the CORO2A gene.[5]
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 5 WD repeats, and has a structural similarity with actin-binding proteins: the D. discoideum coronin and the human p57 protein, suggesting that this protein may also be an actin-binding protein that regulates cell motility. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008].[5]
Jin Y, Birlea SA, Fain PR, Mailloux CM, Riccardi SL, Gowan K, Holland PJ, Bennett DC, Wallace MR, McCormack WT, Kemp EH, Gawkrodger DJ, Weetman AP, Picardo M, Leone G, Taïeb A, Jouary T, Ezzedine K, van Geel N, Lambert J, Overbeck A, Spritz RA (July 2010). "Common variants in FOXP1 are associated with generalized vitiligo". Nature Genetics. 42 (7): 576–8. doi:10.1038/ng.602. PMC2893242. PMID20526340.
Zaphiropoulos PG, Toftgård R (December 1996). "cDNA cloning of a novel WD repeat protein mapping to the 9q22.3 chromosomal region". DNA and Cell Biology. 15 (12): 1049–56. doi:10.1089/dna.1996.15.1049. PMID8985118.
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