CTCFL

CTCFL
Identifiers
Aliases	CTCFL, BORIS, CT27, CTCF-T, HMGB1L1, dJ579F20.2, CCCTC-binding factor like
External IDs	OMIM: 607022 MGI: 3652571 HomoloGene: 46476 GeneCards: CTCFL
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.31 Start 57,495,966 bp[1] End 57,525,652 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H3 Start 172,935,402 bp[2] End 172,961,318 bp[2]
RNA expression pattern Bgee Top expressed in testicle ovary material anatomical entity multicellular organism liver Right lobe of liver thymus More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding sequence-specific DNA binding histone binding GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific metal ion binding GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0001948 protein binding nucleic acid binding GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus cytoplasm Biological process regulation of gene expression by genetic imprinting regulation of transcription, DNA-templated regulation of histone H3-K4 methylation DNA methylation involved in gamete generation transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of gene expression cell cycle histone methylation positive regulation of transcription by RNA polymerase II transcription by RNA polymerase II chromatin organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	140690	664799
Ensembl	ENSG00000124092	ENSMUSG00000070495
UniProt	Q8NI51	A2APF3
RefSeq (mRNA)	NM_001269040 NM_001269041 NM_001269042 NM_001269043 NM_001269044 NM_001269045 NM_001269046 NM_001269047 NM_001269048 NM_001269049 NM_001269050 NM_001269051 NM_001269052 NM_001269054 NM_001269055 NM_080618 NM_001386993 NM_001386994 NM_001386995 NM_001386996 NM_001386997	NM_001081387 NM_001355185
RefSeq (protein)	NP_001255969 NP_001255970 NP_001255971 NP_001255972 NP_001255973 NP_001255974 NP_001255975 NP_001255976 NP_001255977 NP_001255978 NP_001255979 NP_001255980 NP_001255981 NP_001255983 NP_001255984 NP_542185	NP_001074856 NP_001342114
Location (UCSC)	Chr 20: 57.5 – 57.53 Mb	Chr 2: 172.94 – 172.96 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Transcriptional repressor CTCFL also known as BORIS (Brother of Regulator of Imprinted Sites) is a protein that in humans is encoded by the CTCFL gene.^[5]

Function[]

CCCTC-binding factor (CTCF), an 11-zinc finger factor involved in gene regulation, utilizes different zinc fingers to bind varying DNA target sites. CTCF forms methylation-sensitive insulators that regulate X-chromosome inactivation. Transcriptional repressor CTCFL (this protein) is a paralog of CTCF and appears to be expressed primarily in the cytoplasm of spermatocytes, unlike CTCF which is expressed primarily in the nucleus of somatic cells. CTCF and CTCFL are normally expressed in a mutually exclusive pattern that correlates with resetting of methylation marks during male germ cell differentiation.^[5]

References[]

Further reading[]

External links[]

• FactorBook CTCFL
• Human CTCFL genome location and CTCFL gene details page in the UCSC Genome Browser.

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