CTP synthase 1

CTPS1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2VO1
Identifiers
Aliases	CTPS1, CTPS, IMD24, CTP synthase 1, GATD5
External IDs	OMIM: 123860 MGI: 1858304 HomoloGene: 20446 GeneCards: CTPS1
Gene location (Human)
Chr.	Chromosome 1 (human)
End	41,012,565 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	120,570,276 bp
Gene ontology
Molecular function	• nucleotide binding; • ligase activity; • ATP binding; • CTP synthase activity; • identical protein binding;
Cellular component	• cytosol; • membrane; • cytoplasm; • cytoophidium;
Biological process	• T cell proliferation; • B cell proliferation; • nucleobase-containing small molecule interconversion; • glutamine metabolic process; • nucleobase-containing compound metabolic process; • 'de novo' CTP biosynthetic process; • pyrimidine nucleotide biosynthetic process; • immune system process; • CTP biosynthetic process; • pyrimidine nucleobase biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	1503
	51797
	ENSG00000171793
	ENSMUSG00000028633
	P17812
	P70698
	NM_001301237; NM_001905
	NM_016748; NM_001355491
	NP_001288166; NP_001896
	NP_058028; NP_001342420
	Wikidata
View/Edit Human	View/Edit Mouse

CTP synthase 1 is an enzyme that in human s is encoded by the CTPS gene.^[5]^[6]

Function[]

The catalytic conversion of uridine triphosphate (UTP) to cytidine triphosphate (CTP) is accomplished by the enzyme cytidine-5-prime-triphosphate synthetase. This enzyme is important in the biosynthesis of phospholipids and nucleic acids, and plays a key role in cell growth, development, and tumorigenesis.^[6]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000171793 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028633 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yamauchi M, Yamauchi N, Phear G, Spurr NK, Martinsson T, Weith A, Meuth M (December 1991). "Genomic organization and chromosomal localization of the human CTP synthetase gene (CTPS)". Genomics. 11 (4): 1088–96. doi:10.1016/0888-7543(91)90036-E. PMID 1783378.
^ ^a ^b "Entrez Gene: CTP synthase".

External links[]

Human CTPS1 genome location and CTPS1 gene details page in the UCSC Genome Browser.
Overview of all the structural information available in the PDB for UniProt: P17812 (CTP synthase 1) at the PDBe-KB.

Further reading[]

Thomas PE, Lamb BJ, Chu EH (1988). "Purification of cytidine-triphosphate synthetase from rat liver, and demonstration of monomer, dimer and tetramer" (PDF). Biochim. Biophys. Acta. 953 (3): 334–44. doi:10.1016/0167-4838(88)90042-8. hdl:2027.42/27539. PMID 3355843.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
Verschuur AC, Van Gennip AH, Muller EJ, et al. (1999). "Cytidine triphosphate synthase activity and mRNA expression in normal human blood cells". Biol. Chem. 380 (1): 41–6. doi:10.1515/BC.1999.005. PMID 10064135. S2CID 43352567.
Yamauchi M, Yamauchi N, Meuth M (1990). "Molecular cloning of the human CTP synthetase gene by functional complementation with purified human metaphase chromosomes". EMBO J. 9 (7): 2095–9. doi:10.1002/j.1460-2075.1990.tb07377.x. PMC 551928. PMID 2113467.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Higgins MJ, Loiselle D, Haystead TA, Graves LM (2008). "Human cytidine triphosphate synthetase 1 interacting proteins". Nucleosides Nucleotides Nucleic Acids. 27 (6): 850–7. doi:10.1080/15257770802146502. PMID 18600551. S2CID 33594588.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Higgins MJ, Graves PR, Graves LM (2007). "Regulation of human cytidine triphosphate synthetase 1 by glycogen synthase kinase 3". J. Biol. Chem. 282 (40): 29493–503. doi:10.1074/jbc.M703948200. PMID 17681942.
Takahashi E, Yamauchi M, Tsuji H, et al. (1991). "Chromosome mapping of the human cytidine-5'-triphosphate synthetase (CTPS) gene to band 1p34.1-p34.3 by fluorescence in situ hybridization". Hum. Genet. 88 (1): 119–21. doi:10.1007/BF00204942. PMID 1959918. S2CID 21062598.
Whelan J, Phear G, Yamauchi M, Meuth M (1993). "Clustered base substitutions in CTP synthetase conferring drug resistance in Chinese hamster ovary cells". Nat. Genet. 3 (4): 317–22. doi:10.1038/ng0493-317. PMID 7981751. S2CID 34685308.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Gevaert K, Staes A, Van Damme J, et al. (2005). "Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC". Proteomics. 5 (14): 3589–99. doi:10.1002/pmic.200401217. PMID 16097034. S2CID 895879.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Han GS, Sreenivas A, Choi MG, et al. (2005). "Expression of Human CTP Synthetase in Saccharomyces cerevisiae Reveals Phosphorylation by Protein Kinase A". J. Biol. Chem. 280 (46): 38328–36. doi:10.1074/jbc.M509622200. PMC 1400552. PMID 16179339.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Chang YF, Martin SS, Baldwin EP, Carman GM (2007). "Phosphorylation of Human CTP Synthetase 1 by Protein Kinase C IDENTIFICATION OF Ser462 AND Thr455 AS MAJOR SITES OF PHOSPHORYLATION". J. Biol. Chem. 282 (24): 17613–22. doi:10.1074/jbc.M702799200. PMC 2081159. PMID 17463002.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000171793 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028633 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1783378-5] Yamauchi M, Yamauchi N, Phear G, Spurr NK, Martinsson T, Weith A, Meuth M (December 1991). "Genomic organization and chromosomal localization of the human CTP synthetase gene (CTPS)". Genomics. 11 (4): 1088–96. doi:10.1016/0888-7543(91)90036-E. PMID 1783378.

[entrez-6] "Entrez Gene: CTP synthase".

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