Cytochrome b561 is a protein that in humans is encoded by the CYB561 gene .[5] [6]
Model organisms [ ] Model organisms have been used in the study of CYB561 function. A conditional knockout mouse line, called Cyb561tm1a(EUCOMM)Wtsi [13] [14] International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[15] [16] [17]
Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[11] [18] mutant mice and one significant abnormality was observed: female homozygotes displayed a decreased circulating glucose level after a glucose tolerance test .[11]
References [ ]
^ a b c GRCh38: Ensembl release 89: ENSG00000008283 - Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019590 - Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ McBride OW, Yi HF, Srivastava M (Nov 1994). "The human cytochrome b561 gene (CYB561) is located at 17q11-qter" . Genomics . 21 (3): 662–3. doi :10.1006/geno.1994.1332 . PMID 7959749 . ^ "Entrez Gene: CYB561 cytochrome b-561" .^ "Dysmorphology data for Cyb561" . Wellcome Trust Sanger Institute.^ "Glucose tolerance test data for Cyb561" . Wellcome Trust Sanger Institute.^ "Salmonella infection data for Cyb561" . Wellcome Trust Sanger Institute.^ "Citrobacter infection data for Cyb561" . Wellcome Trust Sanger Institute.^ a b c Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica . 88 : 925–7. doi :10.1111/j.1755-3768.2010.4142.x . S2CID 85911512 . ^ Mouse Resources Portal , Wellcome Trust Sanger Institute.^ "International Knockout Mouse Consortium" . Archived from the original on 2012-03-20. Retrieved 2012-02-10 .^ "Mouse Genome Informatics" .^ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function" . Nature . 474 (7351): 337–342. doi :10.1038/nature10163 . PMC 3572410 PMID 21677750 . ^ Dolgin E (2011). "Mouse library set to be knockout" . Nature . 474 (7351): 262–3. doi :10.1038/474262a PMID 21677718 . ^ Collins FS, Rossant J, Wurst W (2007). "A Mouse for All Reasons" . Cell . 128 (1): 9–13. doi :10.1016/j.cell.2006.12.018 PMID 17218247 . S2CID 18872015 . ^ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism" . Genome Biol . 12 (6): 224. doi :10.1186/gb-2011-12-6-224 . PMC 3218837 PMID 21722353 .
External links [ ] Further reading [ ]
Duong LT, Fleming PJ (1982). "Isolation and properties of cytochrome b561 from bovine adrenal chromaffin granules" . J. Biol. Chem . 257 (15): 8561–4. doi :10.1016/S0021-9258(18)34156-5 PMID 7096323 . Srivastava M (1995). "Genomic structure and expression of the human gene encoding cytochrome b561, an integral protein of the chromaffin granule membrane" . J. Biol. Chem . 270 (39): 22714–20. doi :10.1074/jbc.270.39.22714 PMID 7559396 . Srivastava M, Gibson KR, Pollard HB, Fleming PJ (1994). "Human cytochrome b561: a revised hypothesis for conformation in membranes which reconciles sequence and functional information" . Biochem. J . 303 (Pt 3): 915–21. doi :10.1042/bj3030915 . PMC 1137633 PMID 7980462 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Bashtovyy D, Bérczi A, Asard H, Páli T (2004). "Structure prediction for the di-heme cytochrome b561 protein family". Protoplasma . 221 (1–2): 31–40. doi :10.1007/s00709-002-0065-0 . PMID 12768339 . S2CID 21792788 . Kang MK, Kameta A, Shin KH, et al. (2003). "Senescence-associated genes in normal human oral keratinocytes". Exp. Cell Res . 287 (2): 272–81. doi :10.1016/S0014-4827(03)00061-2 . PMID 12837283 . Vargas JD, Herpers B, McKie AT, et al. (2003). "Stromal cell-derived receptor 2 and cytochrome b561 are functional ferric reductases". Biochim. Biophys. Acta . 1651 (1–2): 116–23. doi :10.1016/S1570-9639(03)00242-5 . PMID 14499595 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 .
