Calmodulin 1

CALM1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2VAY, 1Y6W, 4JPZ, 3UCY, 1WRZ, 4G28, 1ZOT, 1YRT, 1IQ5, 1CDL, 2LL6, 3HR4, 4BW7, 4BW8, 1YR5, 4J9Y, 4LZX, 1L7Z, 1ZUZ, 2BE6, 2V01, 1XFV, 2M55, 1CTR, 2I08, 2MG5, 2R28, 3O77, 4UPU, 2L7L, 2K0F, 2M0K, 4V0C, 1SW8, 2WEL, 3DVK, 2M0J, 3DVM, 2KUH, 1K90, 1K93, 4G27, 1CLL, 2KUG, 1XFX, 4DJC, 2LQC, 2LQP, 4L79, 2W73, 2LV6, 1NKF, 2JZI, 3UCT, 4GOW, 1J7O, 1PK0, 4Q5U, 2V02, 3BYA, 4Q57, 2KNE, 1YRU, 2Y4V, 2L53, 2F3Y, 3O78, 1LVC, 4M1L, 2K0E, 1S26, 4DCK, 1XFW, 3SUI, 2X0G, 3EWV, 1XFY, 2LL7, 4OVN, 3J41, 2BKI, 1SK6, 3DVJ, 3UCW, 2LGF, 4UMO, 3DVE, 4JQ0, 3OXQ, 2K61, 1XFU, 3SJQ, 2K0J, 4BYF, 1J7P, 3G43, 3EWT, 4J9Z, 1XFZ, 2F3Z, 1IWQ, 2N6A, 2HF5, 2N27, 4ZLK, 5COC
Identifiers
Aliases	CALM1, CALML2, CAMI, CPVT4, DD132, PHKD, caM, LQT14, Calmodulin 1, calmodulin 1 (phosphorylase kinase, delta), CAMC, CAMB, CAMIII, CAM3, CAM2
External IDs	OMIM: 114180 HomoloGene: 134804 GeneCards: CALM1
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q32.11 Start 90,396,502 bp[1] End 90,408,268 bp[1]
RNA expression pattern Bgee Top expressed in internal globus pallidus temporal lobe parietal lobe cerebral cortex cerebellar hemisphere occipital lobe dorsolateral prefrontal cortex cerebellum putamen More reference expression data BioGPS n/a
Gene ontology Molecular function calcium ion binding GO:0001948 protein binding calcium channel inhibitor activity protein kinase binding titin binding protein serine/threonine kinase activator activity transmembrane transporter binding metal ion binding protein phosphatase activator activity adenylate cyclase binding disordered domain specific binding inositol-1,4,5-trisphosphate 3-kinase activity ligand-gated ion channel activity adenylate cyclase activator activity protein domain specific binding nitric-oxide synthase regulator activity type 3 metabotropic glutamate receptor binding N-terminal myristoylation domain binding phosphatidylinositol 3-kinase binding protein N-terminus binding calcium-dependent protein binding nitric-oxide synthase binding Cellular component cytoplasm cytosol calcium channel complex extracellular region spindle microtubule neuron projection cytoskeleton nucleus centrosome voltage-gated potassium channel complex extracellular exosome spindle pole growth cone plasma membrane spindle sarcomere nucleoplasm vesicle GO:0097483, GO:0097481 postsynaptic density catalytic complex microtubule organizing center synaptic vesicle membrane mitochondrial membrane protein-containing complex myelin sheath Biological process muscle contraction response to amphetamine positive regulation of protein serine/threonine kinase activity detection of calcium ion Fc-epsilon receptor signaling pathway positive regulation of phosphoprotein phosphatase activity G2/M transition of mitotic cell cycle regulation of high voltage-gated calcium channel activity positive regulation of DNA binding substantia nigra development positive regulation of protein dephosphorylation inositol phosphate metabolic process positive regulation of nitric-oxide synthase activity glycogen catabolic process positive regulation of cyclic-nucleotide phosphodiesterase activity G protein-coupled receptor signaling pathway regulation of cytokinesis regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion regulation of rhodopsin mediated signaling pathway response to corticosterone negative regulation of peptidyl-threonine phosphorylation activation of adenylate cyclase activity regulation of heart rate positive regulation of ryanodine-sensitive calcium-release channel activity response to calcium ion regulation of ryanodine-sensitive calcium-release channel activity regulation of nitric-oxide synthase activity platelet degranulation negative regulation of ryanodine-sensitive calcium-release channel activity MAPK cascade positive regulation of peptidyl-threonine phosphorylation positive regulation of protein autophosphorylation regulation of cardiac muscle contraction regulation of cell communication by electrical coupling involved in cardiac conduction regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum calcium-mediated signaling ion transmembrane transport Wnt signaling pathway, calcium modulating pathway GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity protein methylation establishment of protein localization to membrane establishment of protein localization to mitochondrial membrane regulation of synaptic vesicle endocytosis regulation of synaptic vesicle exocytosis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	801	n/a
Ensembl	ENSG00000198668	n/a
UniProt	P0DP23 P0DP24	n/a
RefSeq (mRNA)	NM_001166106 NM_006888 NM_001363669 NM_001363670	n/a
RefSeq (protein)	NP_001292553 NP_001292554 NP_001292555 NP_001734 NP_001316850 NP_001316851 NP_001316852 NP_001316853 NP_001316854 NP_001316855 NP_005175 NP_008819 NP_001350598 NP_001350599 NP_008819 NP_001292553 NP_001292554 NP_001292555 NP_001734 NP_001316850 NP_001316851 NP_001316852 NP_001316853 NP_001316854 NP_001316855 NP_005175	n/a
Location (UCSC)	Chr 14: 90.4 – 90.41 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

Calmodulin 1 is a protein that in humans is encoded by the CALM1 gene.^[3]

Function[]

Calmodulin 1 is the archetype of the family of calcium-modulated (calmodulin) proteins of which nearly 20 members have been found. They are identified by their occurrence in the cytosol or on membranes facing the cytosol and by a high affinity for calcium. Calmodulin contains 148 amino acids and has 4 calcium-binding EF hand motifs. Its functions include roles in growth and the cell cycle as well as in signal transduction and the synthesis and release of neurotransmitters.^[4]

Interactions[]

Calmodulin 1 has been shown to interact with:

• AKAP9,^[5]
• Androgen receptor,^[6]
• IQGAP1,^[7][8]
• PPEF1,^[9] and
• TRPV1.^[10]

References[]

Further reading[]

External links[]

• UniProt entry^{[permanent dead link]}

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