Cancer in dogs

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A 10-year-old female beagle with oral cancer.

Cancer is the leading cause of death in dogs.[1] It is estimated that 1 in 3 domestic dogs will develop cancer, which is the same incidence of cancer among humans.[2] Dogs can develop a variety of cancers and most are very similar to those found in humans. Dogs can develop carcinomas of epithelial cells and organs, sarcomas of connective tissues and bones, and lymphomas or leukemias of the circulatory system. Selective breeding of dogs has led certain pure-bred breeds to be at high-risk for specific kinds of cancer.[1]

Veterinary oncology is the medical study of cancer in animals, and can be diagnosed and treated by specialized veterinarians called veterinary oncologists.

Causes[]

Cancer is a complex, multifactorial disease.[2] Carcinogenesis is linked with DNA mutations, chromosomal translocations, dysfunctional proteins, and aberrant cell cycle regulators.[1] Cancer alters the DNA of cells and the mutated genetic material is passed on to daughter cells, resulting in neoplasms.[2] The mutated DNA effects genes involved with the cell cycle, classified as either oncogenes or tumor suppressor genes.[2] Oncogenes are responsible for cell proliferation and differentiation.[2] Oncogenes responsible for cell growth are overexpressed in cancerous cells. Tumor suppressor genes prevent cells with erroneous cell cycles from replicating.[2] Cancer cells ignore cell cycle regulators that control cell growth, division, and death.[2]

The histology of spontaneous tumorigenesis in canines is attributed to the multiplicity and complexity of the disease. The heterogeneity of its development encompasses inherited, epigenetic, and environmental factors.[2][3]

The selective breeding techniques used with domestic dogs causes certain breeds to be at high risk for specific cancers. Selection for specific phenotypes in dog breeding causes long-range linkage disequilibrium in their DNA.[1] Certain areas of alleles have the tendency to separate less frequently than normal random segregation, which leads to long ranges of repeated DNA sequences. These repeated sequences caused by decreased genetic diversity within breeds, can lead to a high prevalence of certain diseases and especially cancer in breeds. It is believed that the breeding and inbreeding of domesticated canines for specific traits has significantly decreased nucleotide diversity in many pedigree dogs, making certain varieties of canines more susceptible to developing cancer.[4]

Symptoms[]

Symptoms of cancer in dogs may include:

  • Lumps (which are not always malignant, but should always be examined by a vet)
  • Swelling
  • Persistent sores
  • Abnormal discharge from any part of the body
  • Bad breath
  • Listlessness/lethargy
  • Rapid, often unexplained weight loss
  • Sudden lameness
  • Offensive odor
  • Black, tarry stools (a symptom of ulcers, which can be caused by mast cell tumors)
  • Decreased or loss of appetite
  • Difficulty breathing, urinating or defecating[3]

Types of cancer[]

Dogs can develop many of the same types of cancer as humans. Many canine cancers are described with the same terminology and use the same classification systems as human cancers.[1]

Hemangiosarcoma is a type of cancer that develops almost exclusively in dogs, the only two other species known to have it are cats and horses. Hemangiosarcomas are tumors that form on the blood vessels, and can occur all over the body. These tumors can develop on the skin, subcutaneously, or on a blood vessel within an organ and are highly malignant. The tumors are most fatal when they rupture, causing the dog to suffer from severe loss of blood, or hypovolemia.[5]

Dogs are one of three mammalian species that are known to suffer from a transmissible cancer.[6] Canine transmissible venereal tumor (CTVT) is species specific and highly contagious.[6] The cancerous cell lines are transmitted between individuals that are in close contact with each other through acts of intercourse, biting, scratching, or licking.[6] The cancer is prevalent in populations of stray dogs or environments of uncontrolled copulation.[6] The tumors occur around the area of external genitalia and can grow up to 15 cm in area.[6] Canine transmissible venereal tumors can often be infected, ulcerated, and hemorrhagic.[6]

Susceptibility[]

Cancer prevalence in dogs increases with age and certain breeds are more susceptible to specific kinds of cancers. Millions of dogs develop spontaneous tumors each year.[1] Boxers, Boston Terriers and Golden Retrievers are among the breeds that most commonly develop mast cell tumors. Large and giant breeds, like Great Danes, Rottweilers, Greyhound and Saint Bernards, are much more likely to develop bone cancer than smaller breeds.[1] Lymphoma occurs at increased rates in Bernese Mountain dogs, bulldogs, and boxers.[1] It is important for the owner to be familiar with the diseases to which their specific breed of dog might have a breed predisposition.[3]

A study of 144 female dogs found that dogs eating higher amounts of red meat, especially beef and pork, were more likely to get mammary cancer.[7][8]

Treatment[]

Treatment options vary and depend on the type and stage of cancer. Common treatments include surgery, chemotherapy, radiation therapy, amputation, and immunotherapy. A combination of therapies may be used. Knowledge and treatment of cancer have increased significantly in the past three decades. Survival rates have also increased due to the increased prevalence of canine cancer treatment centers and breakthroughs in targeted drug development. Canine cancer treatment has become an accepted clinical practice and access to treatment for owners has widely expanded recently.[2] Cancer-targeting drugs most commonly function to inhibit excessive cell proliferation by attacking the replicating cells.[5]

There is one canine tumor vaccine approved by the USDA, for preventing canine melanoma.[9] The Oncept vaccine activates T-cell responses and antibodies against tumor-specific tyrosinase proteins.[9] There is limited information about canine tumor antigens, which is the reason for the lack of tumor-specific vaccines and immunotherapy treatment plans for dogs.[9]

Success of treatment depends on the form and extent of the cancer and the aggressiveness of the therapy. Early detection offers the best chance for successful treatment. The heterogeneity of tumors makes drug development increasingly complex, especially as new causes are discovered. No cure for cancer in canines exist.[2]

Some dog owners opt for no treatment of the cancer at all, in which case palliative care, including pain relief, may be offered. Regardless of how treatment proceeds following a diagnosis, the quality of life of the pet is an important consideration. In cases where the cancer is not curable, there are still many things which can be done to alleviate the dog's pain. Good nutrition and care from the dog's owner can greatly enhance quality of life.[3]

Prognosis[]

According to Blue Cross, pet owners can expect for their pet to live about 12 months with current treatments. If the owner opts for palliative care instead of treatment, the dog will live about 3 months, although if the tumor is partially removed this can be extended. The survival time may be longer in large dogs, and the cure rate is 20%. If a tumor is completely removed, usually the pet will receive small doses of radiation in hopes of preventing recurrence. The survival rates are: 1 year: 59%, 3 year: 40%, 5 year: 13%.[10]

References[]

  1. ^ a b c d e f g h i Gardner, Heather L.; Fenger, Joelle M.; London, Cheryl A. (2016). "Dogs as a Model for Cancer". Annual Review of Animal Biosciences. 4 (1): 199–222. doi:10.1146/annurev-animal-022114-110911. PMC 6314649. PMID 26566160.
  2. ^ a b c d e f g h i j Pang, Lisa Y.; Argyle, David J. (2016). "Veterinary oncology: Biology, big data and precision medicine" (PDF). The Veterinary Journal. 213: 38–45. doi:10.1016/j.tvjl.2016.03.009. hdl:20.500.11820/0671e750-5fde-4e2e-8951-4d5c78c1a2ce. PMID 27240913.
  3. ^ a b c d "Pet Care Cancer". ASPCA. Archived from the original on 2014-12-13.
  4. ^ Dobson, Jane (2013). "Breed-Predispositions to Cancer in Pedigree Dogs". ISRN Veterinary Science. 2013: 941275. doi:10.1155/2013/941275. PMC 3658424. PMID 23738139.
  5. ^ a b Pang, L. Y.; Argyle, D. J. (2015). "The evolving cancer stem cell paradigm: Implications in veterinary oncology". The Veterinary Journal. 205 (2): 154–60. doi:10.1016/j.tvjl.2014.12.029. PMID 25634078.
  6. ^ a b c d e f Ganguly, B (2013). "Canine transmissible venereal tumour: a review". Veterinary and Comparative Oncology. 14 (1): 1–12. doi:10.1111/vco.12060. PMID 23981098.
  7. ^ Alenza, Dolores Pérez; Rutteman, Gerard R.; Peña, Laura; Beynen, Anton C.; Cuesta, Pedro (1998). "Relation between Habitual Diet and Canine Mammary Tumors in a Case-Control Study". Journal of Veterinary Internal Medicine. 12 (3): 132–139. doi:10.1111/j.1939-1676.1998.tb02108.x. ISSN 1939-1676. PMID 9595373. The intake of homemade meals (compared to that of commercial foods) was also significantly related to a higher incidence of tumors and dysplasias. Other significant risk factors were a high intake of red meat, especially beef and pork (...) We found mammary tumor risk to be positively associated with the intake of red meat and negatively associated with the intake of poultry meat. Particularly, the intake of red meat emerged as an independent factor associated with the risk in the multivariate analysis. Epidemiologic studies have revealed an association between human breast cancer and the consumption of beef and pork and meat; and sausage, eggs, and meat. However, we have not found an association between consumption of vegetables and fruits and mammary tumor development. Higher consumption of vegetables and fruits is associated, although not universally, with a decreased risk of cancer at most sites in humans, especially epithelial cancers of the alimentary and respiratory tracts. The intake of crude fiber, carotene and vitamin C, and fruits and vegetables has been inversely associated with breast cancer risk
  8. ^ Attwood, Diana. "Infopet - Dogs and diet". www.infopet.co.uk. Retrieved 2021-10-21.
  9. ^ a b c Regan, D; Guth, A; Coy, J; Dow, S (2016). "Cancer immunotherapy in veterinary medicine: Current options and new developments". The Veterinary Journal. 207: 20–8. doi:10.1016/j.tvjl.2015.10.008. PMID 26545847.
  10. ^ "Cancer in Dogs | Symptoms and treatment".

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