Christensenella

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Christensenella
Scientific classification
Domain:
Bacteria
Phylum:
Firmicutes
Class:
Clostridia
Order:
Family:
Genus:
Christensenella

Species

Christensenella is a genus of non-spore-forming, anaerobic, and nonmotile bacteria from the family . The species has been published and validated, and and have been proposed as novel species of the genus Christensenella, all isolated from human feces. C. minuta in the gut has been associated with reduction in body weight and adiposity of mice.[6] In a test on 977 volunteers, humans with higher levels of Christensenella in their guts were found to be more likely to have a lower body mass index than those with low levels.[7][8][9] Christensenella are better represented in persons who are metabolically healthy.[9] However, there is a link to possible pathogenic qualities of C. Minuta in humans. An 18 year old male presented with symptoms of appendicitis. Lab work revealed C. Minuta was found in his bloodstream. Upon removal of the appendix, his symptoms and blood levels of C. Minuta disappeared. [10]

References[]

  1. ^ "Taxonomy - Christensenella minuta". UniProt. Retrieved 28 July 2016.
  2. ^ "List of Prokaryotic names with Standing in Nomenclature (LPSN) - Genus Christensenella". LPSN. Retrieved 28 July 2016.
  3. ^ Ndongo, S.; Khelaifia, S.; Fournier, P.-E.; Raoult, D. (2016). "Christensenella massiliensis, a new bacterial species isolated from the human gut". New Microbes and New Infections. 12: 69–70. doi:10.1016/j.nmni.2016.04.014. ISSN 2052-2975. PMC 4909720. PMID 27330817.open access
  4. ^ Morotomi, M.; Nagai, F.; Watanabe, Y. (2011). "Description of Christensenella minuta gen. nov., sp. nov., isolated from human faeces, which forms a distinct branch in the order Clostridiales, and proposal of Christensenellaceae fam. nov". International Journal of Systematic and Evolutionary Microbiology. 62 (1): 144–149. doi:10.1099/ijs.0.026989-0. ISSN 1466-5026. PMID 21357455.open access
  5. ^ Ndongo, S.; Dubourg, G.; Khelaifia, S.; Fournier, P.-E.; Raoult, D. (2016). "Christensenella timonensis, a new bacterial species isolated from the human gut". New Microbes and New Infections. 13: 32–33. doi:10.1016/j.nmni.2016.05.010. ISSN 2052-2975. PMC 4925455. PMID 27408737.open access
  6. ^ The human gut bacterium Christensenella minuta reduces weight and adiposity gains in mice, Jillian L. Waters, Julia K. Goodrich, Ruth E. Ley, Department of Molecular Biology and Genetics, Department of Microbiology, Cornell University Basic presentation of results.
  7. ^ Goodrich, Julia K.; Waters, Jillian L.; Poole, Angela C.; Sutter, Jessica L.; Koren, Omry; Blekhman, Ran; Beaumont, Michelle; Van Treuren, William; Knight, Rob; Bell, Jordana T.; Spector, Timothy D.; Clark, Andrew G.; Ley, Ruth E. (2014). "Human Genetics Shape the Gut Microbiome". Cell. 159 (4): 789–799. doi:10.1016/j.cell.2014.09.053. ISSN 0092-8674. PMC 4255478. PMID 25417156.open access
  8. ^ Jessica Hamzelou (6 November 2014). "Composition of your gut bacteria may be inherited". New Scientist. Retrieved 28 July 2016.
  9. ^ a b Stenman LK, Burcelin R, Lahtinen S (2015). "Establishing a causal link between gut microbes, body weight gain and glucose metabolism in humans - towards treatment with probiotics". Beneficial Microbes. 7 (1): 11–22. doi:10.3920/BM2015.0069. PMID 26565087.
  10. ^ Alonso, B. L., Irigoyen von Sierakowski, A., Sáez Nieto, J. A., & Rosel, A. B. (2017). First report of human infection by Christensenella minuta, a gram-negative, strickly anaerobic rod that inhabits the human intestine. Anaerobe, 44, 124–125. https://doi.org/10.1016/j.anaerobe.2017.03.007


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