Citiolone

Citiolone
Clinical data
ATC code	A05BA04 (WHO) ;
Identifiers
	IUPAC name (RS)-N-(2-Oxothiolan-3-yl)acetamide;
CAS Number	1195-16-0 ;
PubChem CID	14520;
ChemSpider	13864 ;
UNII	70JKL15MUH;
KEGG	D07105 ;
ChEMBL	ChEMBL2104457 ;
CompTox Dashboard (EPA)	DTXSID0045888 ;
ECHA InfoCard	100.013.449
Chemical and physical data
Formula	C6H9NO2S
Molar mass	159.20 g·mol−1
	InChI InChI=1S/C6H9NO2S/c1-4(8)7-5-2-3-10-6(5)9/h5H,2-3H2,1H3,(H,7,8) ; Key:NRFJZTXWLKPZAV-UHFFFAOYSA-N ;
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Citiolone is a drug used in liver therapy.

It is a derivative of the amino acid cysteine.^[1] Citilone has also been studied with regards to hypothermia due to it being a hydroxyl free radical scavenger. The drug has been shown to protect hamster cells subjected to temperature conditions of 8-25 °C.^[2]

References[]

^ de Barrio M, Tornero P, Prieto A, Sainza T, Zubeldia JM, Herrero T (1997). "Recurrent fixed drug eruption caused by citiolone". Journal of Investigational Allergology & Clinical Immunology. 7 (3): 193–4. PMID 9252880.
^ Kruuv, J.; Glofcheski, D.J. (1993). "Further Evidence for Two Modes of Hypothermia Damage". Cryobiology. 30 (3): 313–321. doi:10.1006/cryo.1993.1030. PMID 8370318.

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[1] Barrio M, Tornero P, Prieto A, Sainza T, Zubeldia JM, Herrero T (1997). "Recurrent fixed drug eruption caused by citiolone". Journal of Investigational Allergology & Clinical Immunology. 7 (3): 193–4. PMID 9252880.

[2] Kruuv, J.; Glofcheski, D.J. (1993). "Further Evidence for Two Modes of Hypothermia Damage". Cryobiology. 30 (3): 313–321. doi:10.1006/cryo.1993.1030. PMID 8370318.

[1]

[2]

v t Bile and liver therapy (A05)
Bile therapy	bile acid Chenodeoxycholic acid Cholic acid Obeticholic acid Ursodeoxycholic acid Cyclobutyrol Hymecromone Nicotinyl methylamide Piprozolin
Liver therapy	Arginine glutamate Citiolone Epomediol Glycyrrhizin Metadoxine Ornithine oxoglutarate Silymarin Tidiacic arginine

Clinical data

ATC code	A05BA04 (WHO)
Identifiers
IUPAC name (RS)-N-(2-Oxothiolan-3-yl)acetamide
CAS Number	1195-16-0^Y
PubChem CID	14520
ChemSpider	13864^Y
UNII	70JKL15MUH
KEGG	D07105^Y
ChEMBL	ChEMBL2104457^N
CompTox Dashboard (EPA)	DTXSID0045888
ECHA InfoCard	100.013.449
Chemical and physical data
Formula	C₆H₉NO₂S
Molar mass	159.20 g·mol⁻¹
InChI InChI=1S/C6H9NO2S/c1-4(8)7-5-2-3-10-6(5)9/h5H,2-3H2,1H3,(H,7,8)^Y Key:NRFJZTXWLKPZAV-UHFFFAOYSA-N^Y
^NY (what is this?)