Complement component 7
C7 | |||||||||||||||||||||||||
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Aliases | C7, complement component 7, complement C7 | ||||||||||||||||||||||||
External IDs | OMIM: 217070 MGI: 88235 HomoloGene: 489 GeneCards: C7 | ||||||||||||||||||||||||
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Orthologs | |||||||||||||||||||||||||
Species | Human | Mouse | |||||||||||||||||||||||
Entrez | |||||||||||||||||||||||||
Ensembl | |||||||||||||||||||||||||
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Location (UCSC) | Chr 5: 40.91 – 40.98 Mb | Chr 15: 5.02 – 5.09 Mb | |||||||||||||||||||||||
PubMed search | [3] | [4] | |||||||||||||||||||||||
Wikidata | |||||||||||||||||||||||||
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Complement component 7 is a protein involved in the complement system of the innate immune system. C7 is part of the membrane attack complex (MAC) which creates a hole on pathogen surfaces, leading to cell lysis and death.
Its primary task is to bind the C5bC6 complex together. This junction alters the configuration of the protein molecules, exposing a hydrophobic site on C7 that allows the C7 to insert into the phospholipid bilayer of the pathogen.
See also[]
External links[]
- Complement+C7 at the US National Library of Medicine Medical Subject Headings (MeSH)
- Overview of all the structural information available in the PDB for UniProt: P10643 (Human Complement component C7) at the PDBe-KB.
References[]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000112936 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000079105 - Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Categories:
- Genes on human chromosome 5
- Complement system
- Human chromosome 5 gene stubs