Cytokine dependent hematopoietic cell linker is a protein that in humans is encoded by the CLNK gene.
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Function[]
MIST is a member of the SLP76 family of adaptors (see LCP2, MIM 601603; BLNK, MIM 604515). MIST plays a role in the regulation of immunoreceptor signaling, including PLC-gamma (PLCG1; MIM 172420)-mediated B cell antigen receptor (BCR) signaling and FC-epsilon R1 (see FCER1A, MIM 147140)-mediated mast cell degranulation (Cao et al., 1999 [PubMed 10562326]; Goitsuka et al., 2000, 2001 [PubMed 10744659] [PubMed 11463797]).
Jin TB, Ren Y, Shi X, Jiri M, He N, Feng T, Yuan D, Kang L (2015). "Genetic variations in the CLNK gene and ZNF518B gene are associated with gout in case-control sample sets". Rheumatol. Int. 35 (7): 1141–7. doi:10.1007/s00296-015-3215-3. PMID25591661. S2CID23426576.