DHRS4

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DHRS4

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
3O4R

Identifiers

DHRS4, CR, NRDR, PHCR, PSCD, SCAD-SRL, SDR-SRL, SDR25C1, SDR25C2, dehydrogenase/reductase (SDR family) member 4, dehydrogenase/reductase 4

External IDs

OMIM: 611596 MGI: 90169 HomoloGene: 49646 GeneCards: DHRS4

Gene location (Human)

Chr.	Chromosome 14 (human)^[1]

Band	14q11.2	Start	23,953,734 bp^[1]
Band	14q11.2	End	23,969,279 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 14 (mouse)^[2]

Band	14 C3\|14 28.19 cM	Start	55,478,758 bp^[2]
Band	14 C3\|14 28.19 cM	End	55,490,340 bp^[2]

RNA expression pattern

Top expressed in
kidney liver testicle left ventricle brain Right lobe of liver duodenum
More reference expression data


More reference expression data

Gene ontology
Molecular function	oxidoreductase activity alcohol dehydrogenase [NAD(P)+ activity] signaling receptor binding oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor carbonyl reductase (NADPH) activity 3-keto sterol reductase activity NADP-retinol dehydrogenase activity
Cellular component	peroxisomal membrane peroxisome extracellular exosome endoplasmic reticulum membrane mitochondrion nucleus peroxisomal matrix cytosol
Biological process	steroid metabolic process alcohol metabolic process protein tetramerization cellular ketone metabolic process retinol metabolic process protein targeting to peroxisome
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


10901


28200

Ensembl


ENSG00000157326 ENSG00000284807


ENSMUSG00000022210


Q9BTZ2


Q99LB2

RefSeq (mRNA)

NM_001282987 NM_001282988 NM_001282989 NM_001282990 NM_001282991
NM_021004


NM_001037938 NM_030686

RefSeq (protein)

NP_001269916 NP_001269917 NP_001269918 NP_001269919 NP_001269920
NP_066284


NP_001033027 NP_109611

Location (UCSC)

Chr 14: 23.95 – 23.97 Mb

Chr 14: 55.48 – 55.49 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Dehydrogenase/reductase SDR family member 4 is an enzyme that in humans is encoded by the DHRS4 gene.^[5]^[6]^[7]

References[]

^ ^a ^b ^c ENSG00000284807 GRCh38: Ensembl release 89: ENSG00000157326, ENSG00000284807 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022210 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Fransen M, Van Veldhoven PP, Subramani S (Jul 1999). "Identification of peroxisomal proteins by using M13 phage protein VI phage display: molecular evidence that mammalian peroxisomes contain a 2,4-dienoyl-CoA reductase". Biochem J. 340 ( Pt 2) (Pt 2): 561–8. doi:10.1042/bj3400561. PMC 1220285. PMID 10333503.
^ Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (Short-Chain Dehydrogenase/Reductase and Related Enzymes) Nomenclature Initiative". Chem Biol Interact. 178 (1–3): 94–8. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
^ "Entrez Gene: DHRS4 dehydrogenase/reductase (SDR family) member 4".

Further reading[]

Song XH, Liang B, Liu GF, et al. (2007). "Expression of a novel alternatively spliced variant of NADP(H)-dependent retinol dehydrogenase/reductase with deletion of exon 3 in cervical squamous carcinoma". Int. J. Cancer. 120 (8): 1618–26. doi:10.1002/ijc.22306. PMID 17230527.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Du J, Huang DY, Liu GF, et al. (2004). "CDNA cloning of a short isoform of human liver NADP (H) -dependent retinol dehydrogenase/reductase and analysis of its characteristics". Yi Chuan Xue Bao. 31 (7): 661–7. PMID 15473316.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

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