In molecular biology, disrupted in schizophrenia 2 (non-protein coding), also known as DISC2, is a long non-coding RNA molecule. In humans, the DISC2 gene that produces the DISC2 RNA molecule is located on chromosome 1, at the breakpoint associated with the chromosomal translocation found in Schizophrenia.[2] It is antisense to the DISC1 gene and may regulate the expression of DISC1.[2][3] DISC2 may also contribute to other psychiatric disorders.[3][4]
See also[]
Long noncoding RNA
References[]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Devon RS, Anderson S, Teague PW, Burgess P, Kipari TM, Semple CA, Millar JK, Muir WJ, Murray V, Pelosi AJ, Blackwood DH, Porteous DJ (Jun 2001). "Identification of polymorphisms within Disrupted in Schizophrenia 1 and Disrupted in Schizophrenia 2, and an investigation of their association with schizophrenia and bipolar affective disorder". Psychiatric Genetics. 11 (2): 71–78. doi:10.1097/00041444-200106000-00003. PMID11525420. S2CID10805910.
Taylor MS, Devon RS, Millar JK, Porteous DJ (Jan 2003). "Evolutionary constraints on the Disrupted in Schizophrenia locus". Genomics. 81 (1): 67–77. doi:10.1016/S0888-7543(02)00026-5. PMID12573262.
Millar JK, James R, Brandon NJ, Thomson PA (2004). "DISC1 and DISC2: discovering and dissecting molecular mechanisms underlying psychiatric illness". Annals of Medicine. 36 (5): 367–378. doi:10.1080/07853890410033603. PMID15478311. S2CID36081296.
Farmer A, Elkin A, McGuffin P (Jan 2007). "The genetics of bipolar affective disorder". Current Opinion in Psychiatry. 20 (1): 8–12. doi:10.1097/YCO.0b013e3280117722. PMID17143075. S2CID1512643.