DKK4

DKK4
Identifiers
Aliases	DKK4, DKK-4, dickkopf WNT signaling pathway inhibitor 4
External IDs	OMIM: 605417 MGI: 2385299 HomoloGene: 8680 GeneCards: DKK4
Gene location (Human)
Chr.	Chromosome 8 (human)
End	42,377,229 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	23,117,563 bp
RNA expression pattern
	Top expressed in
	quadriceps femoris muscle; ; amygdala; ; pituitary gland; ; prostate; ; vastus lateralis muscle; ; cerebral cortex; ; cerebellar hemisphere; ; cerebellum;
	More reference expression data
	n/a
Gene ontology
Molecular function	molecular function; co-receptor binding; receptor antagonist activity;
Cellular component	extracellular region; cellular component; extracellular space;
Biological process	multicellular organism development; negative regulation of Wnt signaling pathway; Wnt signaling pathway; negative regulation of canonical Wnt signaling pathway; negative regulation of hair follicle placode formation; extracellular negative regulation of signal transduction; negative regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	27121
	234130
	ENSG00000104371
	ENSMUSG00000031535
	Q9UBT3
	Q8VEJ3
	NM_014420
	NM_145592
	NP_055235
	NP_663567
	Wikidata
View/Edit Human	View/Edit Mouse

Dickkopf-related protein 4 is a protein in the Dickkopf family that in humans is encoded by the DKK4 gene.^[5]

In 2021, it was discovered by researchers at the Stanford University School of Medicine, that the gene is responsible for patterns on cats.^[6]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000104371 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031535 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Krupnik VE, Sharp JD, Jiang C, Robison K, Chickering TW, Amaravadi L, et al. (October 1999). "Functional and structural diversity of the human Dickkopf gene family". Gene. 238 (2): 301–13. doi:10.1016/S0378-1119(99)00365-0. PMID 10570958.
^ Armitage, Hanae (7 September 2021). "Spots, stripes and blotches: Color patterns of cat fur tracked to a key gene". Stanford University School of Medicine. Retrieved 21 December 2021.

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