Disks large-associated protein 5 (DAP-5) also known as discs large homolog 7 (DLG7) or hepatoma up-regulated protein (HURP) is a protein that in humans is encoded by the DLGAP5 gene .[5] [6] [7] [8]
DLG7 is a kinetochore protein that stabilizes microtubules in vicinity of chromosomes . DLG7 controls spindle dynamics, promotes interkinetochore tension and efficient kinetochore capture.[9] Ran -dependent complex.[10] Aurora A kinase .[11] [12] stem cells .[13]
References [ ]
^ a b c GRCh38: Ensembl release 89: ENSG00000126787 - Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037544 - Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (Dec 1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1" . DNA Res . 1 (1): 27–35. doi :10.1093/dnares/1.1.27 PMID 7584026 . ^ Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (Dec 1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)" . DNA Res . 1 (1): 47–56. doi :10.1093/dnares/1.1.47 PMID 7584028 . ^ "Entrez Gene: DLG7 discs, large homolog 7 (Drosophila)" .^ Bassal S, Nomura N, Venter D, Brand K, McKay MJ, van der Spek PJ (September 2001). "Characterization of a novel human cell-cycle-regulated homologue of Drosophila dlg1". Genomics . 77 (1–2): 5–7. doi :10.1006/geno.2001.6570 . PMID 11543626 . ^ Wilde A (June 2006). " . J. Cell Biol . 173 (6): 829–31. doi :10.1083/jcb.200605150 . PMC 2063907 PMID 16785318 . ^ Koffa MD, Casanova CM, Santarella R, Köcher T, Wilm M, Mattaj IW (April 2006). "HURP is part of a Ran-dependent complex involved in spindle formation" . Curr. Biol . 16 (8): 743–54. doi :10.1016/j.cub.2006.03.056 PMID 16631581 . ^ Yu CT, Hsu JM, Lee YC, Tsou AP, Chou CK, Huang CY (July 2005). "Phosphorylation and stabilization of HURP by Aurora-A: implication of HURP as a transforming target of Aurora-A" . Mol. Cell. Biol . 25 (14): 5789–800. doi :10.1128/MCB.25.14.5789-5800.2005 . PMC 1168800 PMID 15987997 . ^ Sanderson HS, Clarke PR (June 2006). "Cell biology: Ran, mitosis and the cancer connection" . Curr. Biol . 16 (12): R466–8. doi :10.1016/j.cub.2006.05.032 PMID 16782004 . ^ Gudmundsson KO, Thorsteinsson L, Sigurjonsson OE, et al. (June 2007). "Gene expression analysis of hematopoietic progenitor cells identifies Dlg7 as a potential stem cell gene". Stem Cells . 25 (6): 1498–506. doi :10.1634/stemcells.2005-0479 . PMID 17322106 . S2CID 25347875 .
Further reading [ ]
Ohara O, Nagase T, Ishikawa K, et al. (1997). "Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins" . DNA Res . 4 (1): 53–9. doi :10.1093/dnares/4.1.53 PMID 9179496 . Bassal S, Nomura N, Venter D, et al. (2001). "Characterization of a novel human cell-cycle-regulated homologue of Drosophila dlg1". Genomics . 77 (1–2): 5–7. doi :10.1006/geno.2001.6570 . PMID 11543626 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Tsou AP, Yang CW, Huang CY, et al. (2003). "Identification of a novel cell cycle regulated gene, HURP, overexpressed in human hepatocellular carcinoma" . Oncogene . 22 (2): 298–307. doi :10.1038/sj.onc.1206129 PMID 12527899 . Mantovani F, Banks L (2004). "Regulation of the discs large tumor suppressor by a phosphorylation-dependent interaction with the beta-TrCP ubiquitin ligase receptor" . J. Biol. Chem . 278 (43): 42477–86. doi :10.1074/jbc.M302799200 PMID 12902344 . Laprise P, Viel A, Rivard N (2004). "Human homolog of disc-large is required for adherens junction assembly and differentiation of human intestinal epithelial cells" . J. Biol. Chem . 279 (11): 10157–66. doi :10.1074/jbc.M309843200 PMID 14699157 . Shu H, Chen S, Bi Q, et al. (2004). "Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line" . Mol. Cell. Proteomics . 3 (3): 279–86. doi :10.1074/mcp.D300003-MCP200 PMID 14729942 . Hsu JM, Lee YC, Yu CT, Huang CY (2004). "Fbx7 functions in the SCF complex regulating Cdk1-cyclin B-phosphorylated hepatoma up-regulated protein (HURP) proteolysis by a proline-rich region" . J. Biol. Chem . 279 (31): 32592–602. doi :10.1074/jbc.M404950200 PMID 15145941 . Blot V, Delamarre L, Perugi F, et al. (2005). "Human Dlg protein binds to the envelope glycoproteins of human T-cell leukemia virus type 1 and regulates envelope mediated cell-cell fusion in T lymphocytes" . J. Cell Sci . 117 (Pt 17): 3983–93. doi :10.1242/jcs.01266 PMID 15286176 . Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins" . Proc. Natl. Acad. Sci. U.S.A . 101 (33): 12130–5. doi :10.1073/pnas.0404720101 PMC 514446 PMID 15302935 . Zhao L, Qin LX, Ye QH, et al. (2005). "KIAA0008 gene is associated with invasive phenotype of human hepatocellular carcinoma--a functional analysis". J. Cancer Res. Clin. Oncol . 130 (12): 719–27. doi :10.1007/s00432-004-0595-2 . PMID 15340842 . S2CID 24151704 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Yu CT, Hsu JM, Lee YC, et al. (2005). "Phosphorylation and stabilization of HURP by Aurora-A: implication of HURP as a transforming target of Aurora-A" . Mol. Cell. Biol . 25 (14): 5789–800. doi :10.1128/MCB.25.14.5789-5800.2005 . PMC 1168800 PMID 15987997 . Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle" . Proc. Natl. Acad. Sci. U.S.A . 103 (14): 5391–6. doi :10.1073/pnas.0507066103 PMC 1459365 PMID 16565220 . Wong J, Fang G (2006). "HURP controls spindle dynamics to promote proper interkinetochore tension and efficient kinetochore capture" . J. Cell Biol . 173 (6): 879–91. doi :10.1083/jcb.200511132 . PMC 2063914 PMID 16769820 . Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol . 24 (10): 1285–92. doi :10.1038/nbt1240 . PMID 16964243 . S2CID 14294292 . Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–48. doi :10.1016/j.cell.2006.09.026 PMID 17081983 .
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