DUSP3

DUSP3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1J4X, 1VHR, 3F81
Identifiers
Aliases	DUSP3, VHR, dual specificity phosphatase 3
External IDs	OMIM: 600183 MGI: 1919599 HomoloGene: 20870 GeneCards: DUSP3
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.31 Start 43,766,125 bp[1] End 43,778,977 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 D Start 101,861,969 bp[2] End 101,877,839 bp[2]
RNA expression pattern Bgee Top expressed in ventricle vastus lateralis muscle myocardium muscle of leg gastrocnemius muscle biceps brachii heart More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphoprotein phosphatase activity MAP kinase phosphatase activity hydrolase activity protein kinase binding protein tyrosine/serine/threonine phosphatase activity phosphatase activity protein tyrosine phosphatase activity cytoskeletal protein binding receptor tyrosine kinase binding protein tyrosine kinase binding Cellular component cytosol nucleoplasm immunological synapse nucleus Biological process protein dephosphorylation positive regulation of mitotic cell cycle negative regulation of T cell receptor signaling pathway negative regulation of JNK cascade negative regulation of MAPK cascade negative regulation of ERK1 and ERK2 cascade peptidyl-tyrosine dephosphorylation negative regulation of T cell activation in utero embryonic development dephosphorylation negative regulation of cell migration negative regulation of epidermal growth factor receptor signaling pathway negative regulation of chemotaxis regulation of focal adhesion assembly cellular response to epidermal growth factor stimulus positive regulation of focal adhesion disassembly peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1845	72349
Ensembl	ENSG00000108861	ENSMUSG00000003518
UniProt	P51452	Q9D7X3
RefSeq (mRNA)	NM_004090	NM_028207
RefSeq (protein)	NP_004081	NP_082483
Location (UCSC)	Chr 17: 43.77 – 43.78 Mb	Chr 11: 101.86 – 101.88 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Dual specificity protein phosphatase 3 is an enzyme that in humans is encoded by the DUSP3 gene.^[5][6]

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1.^[6]

Model organisms[]

Model organisms have been used in the study of DUSP3 function. A conditional knockout mouse line, called Dusp3^{tm1a(KOMP)Wtsi[14][15]} was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.^[16][17][18]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.^[12][19] Twenty five tests were carried out on mutant mice and four significant abnormalities were observed.^[12] Homozygous mutants had an increased percent of body fat, abnormal humerus morphology and an increased susceptibility to bacterial infection. Corpus callosum area, hippocampus area and total brain section area was increased, while length of pyramidal cell layer was reduced.^[12]

Interactions[]

DUSP3 has been shown to interact with MAPK3^[20] and MAPK1.^[20]

References[]

Further reading[]