Datumetine

Datumetine
Names
	IUPAC name 4-Methoxy-3-(8-methyl-8-azabicyclo[3.2.1]octan-3-yl)benzoic acid
Identifiers
CAS Number	67078-20-0;
3D model (JSmol)	Interactive image;
ChemSpider	158188;
PubChem CID	181868;
CompTox Dashboard (EPA)	DTXSID40986112 ;
	show InChI
	show SMILES
Properties
Chemical formula	C16H21NO3
Molar mass	275.348 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	Infobox references

Datumetine is a tropane alkaloid found in leaves of Datura metel.^[1] It is said to modulate NMDA receptor and thus causes memory loss.^[2] It also causes epileptic seizures in mice.^[2] Docking studies suggest that it fits on both allosteric and sites of NMDA receptor.^[3] It acts together with other anticholinergic tropane alkaloids of datura to cause amnesia.^{[citation needed]}

References[]

^ Siddiqui, Salimuzzaman; Sultana, Naheed; Ahmed, S. Salman; Haider, S. Imtiaz (2004). "Isolation and Structure of a New Alkaloid Datumetine from the leaves of Datura metel". Journal of Natural Products. 49 (3): 511–513. doi:10.1021/np50045a023. ISSN 0163-3864.
^ Jump up to: ^a ^b Ishola AO, Imam A, Ajao MS (2021). "Effects of datumetine on hippocampal NMDAR activity". . 8: 1131–1142. doi:10.1016/j.toxrep.2021.05.009. PMC 8190477. PMID 34150523.
^ Ishola, Azeez Olakunle; Imam, Aminu; Ajao, Moyosore Salihu (2021). "Effects of datumetine on hippocampal NMDAR activity". Toxicology Reports. 8: 1131–1142. doi:10.1016/j.toxrep.2021.05.009. ISSN 2214-7500. PMC 8190477. PMID 34150523.

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[SiddiquiSultana2004-1] Siddiqui, Salimuzzaman; Sultana, Naheed; Ahmed, S. Salman; Haider, S. Imtiaz (2004). "Isolation and Structure of a New Alkaloid Datumetine from the leaves of Datura metel". Journal of Natural Products. 49 (3): 511–513. doi:10.1021/np50045a023. ISSN 0163-3864.

[pmid34150523-2] Jump up to: ^a ^b Ishola AO, Imam A, Ajao MS (2021). "Effects of datumetine on hippocampal NMDAR activity". . 8: 1131–1142. doi:10.1016/j.toxrep.2021.05.009. PMC 8190477. PMID 34150523.

[IsholaImam2021-3] Ishola, Azeez Olakunle; Imam, Aminu; Ajao, Moyosore Salihu (2021). "Effects of datumetine on hippocampal NMDAR activity". Toxicology Reports. 8: 1131–1142. doi:10.1016/j.toxrep.2021.05.009. ISSN 2214-7500. PMC 8190477. PMID 34150523.

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[2]

[3]

Datumetine

See also[]

References[]