David Gius

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Side picture of Gius (man with glasses) giving a speech from a podium
David Gius at a Northwestern event

David R. Gius (born August 23, 1960) is an American physician-scientist[1] the Zell Family Scholar Professor,[2] Women's Cancer Research Program director, and Vice Chair of Translational Research[3] at Northwestern University's Feinberg School of Medicine Department of Radiation Oncology and Pharmacology. His research focuses into the mechanistic connection between aging, cellular and/or mitochondrial metabolism, and carcinogenesis focusing on the Sirtuin gene family.[4]

Education[]

Gius graduated from the University of Illinois at Chicago in 1983 with an undergraduate degree in chemistry. He completed his Ph.D. at the University of Chicago in 1983, and his M.D. at the Loyola University of Chicago Strich School of Medicine in 1992.

Career[]

He did his postdoctoral work in the Molecular Genetics and Cell Biology Department at the University of Chicago in 1993, with Vikas P. Sukhatme and Tom Curran. Afterwards, he moved to St. Louis, MO where he did his residency in Radiation Oncology Resident at the Radiation Oncology Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine. He then served between 1997-2001 as Assistant Professor and Residency Director of the division and the Section of Cancer Biology. Between 2001 and 2009 he was the Chief of the National Cancer Institute’s (NCI) Molecular Radiation Oncology Section. He was also residency director of NCC Radiation Oncology Residency, clinical director of GYN services in the Center for Cancer Research, and a researcher with the NCI in Bethesda, MD. In 2005 he became the Associate Program Director of the National Institutes of Health (NIH) Oxford/Cambridge Scholars and the Trans-NIH MD/PhD Partnership Program.[5] Prior to his current appointment at Northwestern University, he was the Clinical Chief and an Associate Professor (2009-2012) in the Departments of Cancer Biology, Pediatrics, and Radiation Oncology, in the Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN.[1]

Selected publications[]

  • Lysine 68 acetylation directs MnSOD as a tetrameric detoxification complex versus a monomeric tumor promoter. Nature Commun. 10:2399-2414, 2019.[6]
  • Circadian Clock NAD+ Cycle Drives Mitochondrial Oxidative Metabolism in Mice. Science. 342:1243417, 2013.[7]
  • SIRT2 Maintains Genome Integrity and Suppresses Tumorigenesis through Regulating APC/C Activity. Cancer Cell. 20:487-499, 2011.[8]
  • Sirt3-Mediated Deacetylation of Evolutionarily Conserved Lysine 122 Regulates MnSOD Activity in Response to Stress. Molecular Cell. 40:893-904, 2010.[9]
  • SIRT3 is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress. Cancer Cell. 17:41-52, 2010.[10]

Awards[]

References[]

  1. ^ Jump up to: a b ,"Radiation Research Society 2014 Elections Candidate Biographies and Vision Statements" (PDF).
  2. ^ "David Gius, MD, PhD - Translational Cancer Research". tcr.amegroups.com. Retrieved 2020-01-22.
  3. ^ "Gius Named Vice Chair for Translational Research, Radiation Oncology: Robert H. Lurie Comprehensive Cancer Center of Northwestern University : Feinberg School of Medicine: Northwestern University". www.cancer.northwestern.edu. Retrieved 2020-01-22.
  4. ^ "Study Explains Genetic Connection Between Aging and Cancer". Hirshberg Foundation for Pancreatic Cancer Research. 2017-04-04. Retrieved 2020-01-17.
  5. ^ "New radiation oncology researcher joins Vanderbilt (03/19/10)". www.mc.vanderbilt.edu. Retrieved 2020-01-21.
  6. ^ Bose, K. S.; Sarma, R. H. (1975-10-27). "Delineation of the intimate details of the backbone conformation of pyridine nucleotide coenzymes in aqueous solution". Biochemical and Biophysical Research Communications. 66 (4): 1173–1179. doi:10.1016/0006-291x(75)90482-9. ISSN 1090-2104. PMID 2.
  7. ^ Peek, Clara Bien; Affinati, Alison H.; Ramsey, Kathryn Moynihan; Kuo, Hsin-Yu; Yu, Wei; Sena, Laura A.; Ilkayeva, Olga; Marcheva, Biliana; Kobayashi, Yumiko; Omura, Chiaki; Levine, Daniel C. (2013-11-01). "Circadian clock NAD+ cycle drives mitochondrial oxidative metabolism in mice". Science. 342 (6158): 1243417. doi:10.1126/science.1243417. ISSN 1095-9203. PMC 3963134. PMID 24051248.
  8. ^ Kim, Hyun-Seok; Vassilopoulos, Athanassios; Wang, Rui-Hong; Lahusen, Tyler; Xiao, Zhen; Xu, Xiaoling; Li, Cuiling; Veenstra, Timothy D.; Li, Bing; Yu, Hongtao; Ji, Junfang (2011-10-18). "SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity". Cancer Cell. 20 (4): 487–499. doi:10.1016/j.ccr.2011.09.004. ISSN 1878-3686. PMC 3199577. PMID 22014574.
  9. ^ Tao, Randa; Coleman, Mitchell C.; Pennington, J. Daniel; Ozden, Ozkan; Park, Seong-Hoon; Jiang, Haiyan; Kim, Hyun-Seok; Flynn, Charles Robb; Hill, Salisha; Hayes McDonald, W.; Olivier, Alicia K. (2010-12-22). "Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress". Molecular Cell. 40 (6): 893–904. doi:10.1016/j.molcel.2010.12.013. ISSN 1097-4164. PMC 3266626. PMID 21172655.
  10. ^ Kim, Hyun-Seok; Patel, Krish; Muldoon-Jacobs, Kristi; Bisht, Kheem S.; Aykin-Burns, Nukhet; Pennington, J. Daniel; van der Meer, Riet; Nguyen, Phuongmai; Savage, Jason; Owens, Kjerstin M.; Vassilopoulos, Athanassios (2010-01-19). "SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress". Cancer Cell. 17 (1): 41–52. doi:10.1016/j.ccr.2009.11.023. ISSN 1878-3686. PMC 3711519. PMID 20129246.
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